Specific distribution of gabarap, gec1/gabarap Like 1, gate16/gabarap Like 2, lc3 messenger RNAs in rat brain areas by quantitative real-time PCR

Université de Franche-Comté, IFR 133, U.F.R. Sciences et Techniques, Equipe Estrogènes, Expression Génique et Pathologies du Système Nerveux Central, 16 route de Gray, 25030 Besançon cedex, France.
Brain Research (Impact Factor: 2.83). 03/2006; 1073-1074(1):83-7. DOI: 10.1016/j.brainres.2005.11.004
Source: PubMed

ABSTRACT GABARAP and GEC1/GABARAPL1 interact with tubulin and GABA(A) receptor and belong to a new protein family. This family includes GATE 16 and LC3, potentially involved in intracellular transport processes. In this study, we combined brain dissection and quantitative real-time reverse transcription polymerase chain reaction to study discriminatively gabarap, gec1/gabarapL1, gate16/gabarapL2, lc3 mRNA distribution in multiple rat brain areas.

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    • "Since its discovery, GABARAP and its orthologs have been found in almost all organisms as diverse from yeast to human. Human GABARAPs, which are linker proteins between microtubules and g subunit of GABA A receptors are expressed ubiquitously in the central nervous system, and a few in endocrine organs and other tissues [3] [4]. Amphioxus GABARAPs are expressed ubiquitously, with the highest expression in the enteric nervous system, notochord, and ovary, although its precise function is unknown [5] [6]. "
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