Effects of simultaneous intakes of indigestible dextrin and diacylglycerol on lipid profiles in rats fed cholesterol diets

Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, Tokyo, Japan.
Nutrition (Impact Factor: 2.93). 05/2006; 22(4):395-400. DOI: 10.1016/j.nut.2005.08.008
Source: PubMed


Indigestible dextrin (IDex) and diacylglycerol (DG) are food components with physiologic effects on lipid metabolism. Because simultaneous intake of dietary components with similar physiologic functions may produce a beneficial decrease in risk factors for lifestyle-related diseases, we investigated the physiologic effects of simultaneous IDex and DG intake.
Five-week-old male Wistar rats were fed a cholesterol-containing diet with IDex and DG (separately and combined) for 28 d.
IDex significantly decreased serum triacylglycerol concentration and increased the length of small intestinal villi, whereas DG produced significant decreases in serum high-density lipoprotein cholesterol concentration and significant increases in liver cholesterol and triacylglycerol concentrations.
IDex intake characteristically decreased serum triacylglycerol concentrations, although no additive or synergistic interaction between DG and IDex was observed. These results indicate that simultaneous intake of food components with similar physiologic functions do not necessarily produce additive or synergistic physiologic benefits.

6 Reads
  • Source
    • "Neither CH nor MD had any apparently negative effect on animal health, nor did they have any effect on food consumption. As previously reported, MD was not effective at reducing body weight gain (Nagata & Saito, 2006). Results that report the effect of CH on body weight gain are more controversial and seem to be highly dependent on the amount of fat and cholesterol in the diet. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Chitosan, a deacetylated form of chitin, is a dietary fibre known for its hypolipidemic properties, which are mainly attributed to its unique cationic characteristics. We studied the selective in vivo effect of chitosan on fat excretion in order to elucidate its hypolipidemic mechanism. A 4-week longitudinal study was conducted in guinea pigs and the effect of chitosan on fat-absorption was compared to that of a soluble fibre: digestion-resistant maltodextrin. Animals were fed with high-fat isocaloric diets containing 12/100g of cellulose, digestion-resistant maltodextrin or chitosan. Subsequently, the excretion of fatty acids, neutral sterols and bile acids was determined. Chitosan selectively reduced fat absorption in comparison to digestion-resistant maltodextrin. The excretion of lauric, myristic and palmitic fatty acids of animals fed with chitosan was more than 10-, 5- and 2-fold higher, respectively, than in the cellulose group, whereas stearic acid excretion was not significantly altered. Oleic, linoleic and α-linolenic acid excretion were also significantly higher (P<0.001). The n-6/n-3 ratio in faeces of the chitosan group was 23.68, compared to 13.95 in the cellulose group. Total neutral sterol excretion was increased by both dietary fibres, whereas bile acid excretion was only increased by chitosan. Nevertheless, chitosan inhibited the intestinal bioconversion of cholesterol and primary bile acids to secondary metabolites. Hence, these results reveal that chitosan and digestion resistant maltodextrin exert their hypolipidemic activity by different mechanisms.
    Food Chemistry 09/2012; 134(2):940-7. DOI:10.1016/j.foodchem.2012.02.211 · 3.39 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Soapstock and deodorizer distillates are the major by-products from vegetable oil refining. They have little commercial value and are sold at a fraction of the oil cost. However, their characterization reveals the presence of numerous types of compounds, which could be extremely valuable if extracted at low cost. The literature in this area is discontinuous and warrants the effort to produce a comprehensive review. The aim of this review is to combine and condense the body of research performed on these materials, as well as to suggest the best routes for characterization and extraction. Utilization of the components is also discussed.
    Food Research International 10/2007; 40(8-40):957-974. DOI:10.1016/j.foodres.2007.06.006 · 2.82 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Soybean protein (SPI) and diacylglycerol (DAG) are functional components with benefits for lipid metabolism. Since simultaneous intake of such components is expected to exert effects additively and/or synergistically in lifestyle-related diseases, we examined the effects of simultaneous intake of SPI and DAG on lipid profiles. Five-week-old male Wistar rats were fed experimental diets with and without cholesterol for 28 d. In the rats fed cholesterol-free diets, significant interactions between dietary oil and protein were observed in the serum triacylglycerol (TG), hepatic cholesterol, and TG concentrations, whereas in the rats fed cholesterol diets, the serum and hepatic lipid concentrations were significantly lower in rats fed SPI than in those fed casein. Although our results suggest that simultaneous intake of SPI and DAG has slightly ameliorating effects on lipid profiles in rats, simultaneous intake of foods or foods components with similar functions are not necessarily effective.
    Bioscience Biotechnology and Biochemistry 07/2009; 73(6):1328-32. DOI:10.1271/bbb.80893 · 1.06 Impact Factor
Show more