Article

Genetic epidemiology of rheumatoid arthritis.

arc Epidemiology Unit, Manchester University, School of Epidemiology and Health Sciences, Manchester, UK.
Current Opinion in Rheumatology (impact factor: 4.31). 04/2006; 18(2):141-6. DOI:10.1097/01.bor.0000209425.84775.23 pp.141-6
Source: PubMed

ABSTRACT This review aims to summarize articles published between October 2004 and November 2005 that have investigated the genetic epidemiology of rheumatoid arthritis.
The consistent replication of an association between the R620W single nucleotide polymorphism in PTPN22 and rheumatoid arthritis clearly establishes this polymorphism as an important risk factor for rheumatoid arthritis.
Genetic investigations of rheumatoid arthritis have predominantly been single nucleotide polymorphism-based candidate gene association studies searching for markers of susceptibility, severity or treatment response. Studies of the human leukocyte antigen region have refined and added to our understanding of the complex associations to polymorphisms with this locus. PTPN22 has emerged strongly as a genuine rheumatoid arthritis susceptibility gene with replications of the association to the R620W single nucleotide polymorphism. Many investigations have been conducted on the genetics of treatment response -- some 'generic' and others specific in terms of identifying genetic influences to the mode of action and metabolism of particular agents.

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Keywords

'generic'
 
articles
 
complex associations
 
consistent replication
 
genetic epidemiology
 
genetic influences
 
Genetic investigations
 
genuine rheumatoid arthritis susceptibility gene
 
investigations
 
metabolism
 
polymorphism
 
polymorphisms
 
R620W single nucleotide polymorphism
 
replications
 
rheumatoid arthritis
 
risk factor
 
susceptibility
 
treatment response
 

Jacqueline E Oliver