The effect of interaction between hepatitis C virus and cigarette smoking on the risk of hepatocellular carcinoma

Department of Public Health, Kurume University School of Medicine, Kurume 830-0011, Japan.
British Journal of Cancer (Impact Factor: 4.82). 04/2006; 94(5):737-9. DOI: 10.1038/sj.bjc.6602981
Source: PubMed

ABSTRACT We evaluated the interaction between hepatitis C virus (HCV) and cigarette smoking on death from hepatocellular cancer in The Japan Collaborative Cohort Study. The odds ratio of death from HCC for smoking was 9.60 (1.50-61.35) and 1.71(0.58-5.08) among anti-HCV positive and negative individuals, respectively.

  • World Journal of Gastroenterology 01/2010; 16(29):3603. DOI:10.3748/wjg.v16.i29.3603 · 2.43 Impact Factor
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    ABSTRACT: ADVERTIMENT. La consulta d'aquesta tesi queda condicionada a l'acceptació de les següents condicions d'ús: La difusió d'aquesta tesi per mitjà del servei TDX ( ha estat autoritzada pels titulars dels drets de propietat intel·lectual únicament per a usos privats emmarcats en activitats d'investigació i docència. No s'autoritza la seva reproducció amb finalitats de lucre ni la seva difusió i posada a disposició des d'un lloc aliè al servei TDX. No s'autoritza la presentació del seu contingut en una finestra o marc aliè a TDX (framing). Aquesta reserva de drets afecta tant al resum de presentació de la tesi com als seus continguts. En la utilització o cita de parts de la tesi és obligat indicar el nom de la persona autora. ADVERTENCIA. La consulta de esta tesis queda condicionada a la aceptación de las siguientes condiciones de uso: La difusión de esta tesis por medio del servicio TDR ( ha sido autorizada por los titulares de los derechos de propiedad intelectual únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con finalidades de lucro ni su difusión y puesta a disposición desde un sitio ajeno al servicio TDR. No se autoriza la presentación de su contenido en una ventana o marco ajeno a TDR (framing). Esta reserva de derechos afecta tanto al resumen de presentación de la tesis como a sus contenidos. En la utilización o cita de partes de la tesis es obligado indicar el nombre de la persona autora. WARNING. On having consulted this thesis you're accepting the following use conditions: Spreading this thesis by the TDX ( service has been authorized by the titular of the intellectual property rights only for private uses placed in investigation and teaching activities. Reproduction with lucrative aims is not authorized neither its spreading and availability from a site foreign to the TDX service. Introducing its content in a window or frame foreign to the TDX service is not authorized (framing). This rights affect to the presentation summary of the thesis as well as to its contents. In the using or citation of parts of the thesis it's obliged to indicate the name of the author.
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    ABSTRACT: Safe blood transfusion where hepatitis is endemic In South-East Asia the prevalence of hepatitis B and C virus infections is high. Accurate – yet low-cost – screening of blood donors is crucial to avoid transfusion-transmitted disease. On (DATE) Le Viet will defend his thesis “Safe Blood Transfusion: Screening for Hepatitis B and Hepatitis C Virus Infections in Potential Blood Donors in Rural Southeast Asia” for the PhD degree at the Faculty of Health Sciences at UiT. The first aim of the thesis is to identify the accuracy of rapid tests for detection of acute hepatitis B, occult hepatitis B, and hepatitis C virus infections in potential blood donor in rural Vietnam and Cambodia. The second aim is to estimate prevalence of these infections among potential rural blood donors in Vietnam, and to examine the accuracy of enzyme immunoassay (EIA) technique in blood donor screening. The final goal is to estimate the risk of transfusion-transmitted hepatitis B in Vietnamese blood donors based on the available prevalence data and estimated prevalence of occult hepatitis B infection. 2,400 blood samples from potential voluntary rural blood donors in a multicentre cross-sectional study in Cambodia and Vietnam were analysed with rapid and EIA tests for detection of HBsAg, anti-HBc and anti-HCV at local laboratories. 640 randomly selected blood samples were blindly validated in a Norwegian accredited micro-laboratory by a chemiluminescent micro particle immunoassay technique (CMIA). Rapid test for donor screening of hepatitis proved to have far lover accuracy than claimed by the manufacturer; especially the false-negative rate was unacceptably high. The study revealed that hepatitis B infection is endemic in rural Vietnam and almost half of Vietnamese population is or has been infected with hepatitis B while hepatitis C infection is rare. The results indicate that the EIA performance in blood donor screening in Vietnam may be sub-optimal. The major risk factors for post- transfusion are HBsAg false-negative results and potential occult hepatitis B infections. Increased test sensitivity and locally validated HBsAg assays are recommended.
    11/2014, Degree: Philosophy Doctor (PhD), Supervisor: Hans Husums, Anne Husebekk, Eystein Skjerve


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