Article

Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish

Department of Biology, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, USA.
Immunogenetics (Impact Factor: 2.49). 03/2006; 58(1):31-40. DOI: 10.1007/s00251-005-0064-3
Source: PubMed

ABSTRACT The identification of C-type lectin (Group V) natural killer (NK) cell receptors in bony fish has remained elusive. Analyses of the Fugu rubripes genome database failed to identify Group V C-type lectin domains (Zelensky and Gready, BMC Genomics 5:51, 2004) suggesting that bony fish, in general, may lack such receptors. Numerous Group II C-type lectin receptors, which are structurally similar to Group V (NK) receptors, have been characterized in bony fish. By searching the zebrafish genome database we have identified a multi-gene family of Group II immune-related, lectin-like receptors (illrs) whose members possess inhibiting and/or activating signaling motifs typical of Group V NK receptors. Illr genes are differentially expressed in the myeloid and lymphoid lineages, suggesting that they may play important roles in the immune functions of multiple hematopoietic cell lineages.

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    • "In addition to these considerations, the genomes of two species of bony fish, medaka and zebrafish, have been sufficiently resolved and adequately annotated to make possible the consideration of other gene families in the context of what we understand to be the general features of multigene families encoding the polymorphic NK receptors seen in higher vertebrates. Specifically, no compelling evidence exists for sequence orthologs of either KIRs or class V C-type lectin-related receptors (Zelensky and Gready, 2004; Panagos et al., 2008), members of which constitute MHC I receptors on human and mouse NK cells, respectively. "
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