The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins.

Department of Pathology, University of California, San Francisco, 94143, USA.
Current Molecular Medicine (Impact Factor: 3.61). 03/2006; 6(1):99-109. DOI: 10.2174/156652406775574587
Source: PubMed

ABSTRACT Irreversible perturbations in the homeostasis of the endoplasmic reticulum (ER) are thought to lead to apoptosis and cell loss in a number of important human diseases, including Alzheimer disease, Parkinson disease, and type 2 diabetes. However, the exact mechanisms that lead from ER stress to cell death remain incompletely understood. Recent work has shown that the BCL-2 family of proteins plays a central role in regulating this form of cell death, both locally at the ER and from a distance at the mitochondrial membrane.

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