Morbidity and mortality profile of human immunodeficiency virus-infected patients with and without hepatitis C co-infection

Retrovirus Research Center, and Department of Microbiology, Universidad Central del Caribe, School of Medicine, Bayamón, Puerto Rico.
The American journal of tropical medicine and hygiene (Impact Factor: 2.7). 03/2006; 74(2):239-45.
Source: PubMed


Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection is an important and frequent scenario, predominantly in injecting drug users (IDUs). The present study evaluated morbidity and mortality variation in HIV-infected patients with and without HCV co-infection. Co-infection prevalence was determined in 356 HIV-infected persons. Their clinical manifestations, laboratory findings, risk factors, HIV therapies, and mortality rates were evaluated. The prevalence of HCV was 54% in the overall group and 81% in IDUs, with a predominance of HCV genotype 1. Mortality rates were similar in patients with and without co-infection; however, co-infected patients had significantly higher liver damage as a cause of mortality when compared with those who were not co-infected. The high prevalence of HCV and an emerging mortality from liver diseases showed the significance of this co-infection in the HIV epidemic. Primary and secondary prevention are necessary to reduce the expanding impact of HCV infection in HIV patients.

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    • "These HIV/HCV co-infected persons account for approximately 25% of all HIV-infected persons all over the world [1]. Injection drug users (IDUs) are shown to be the highest risk factor of HIV/HCV co-infection [2-5]. According to a study investigation performed in 2008, approximately 63.2% of HIV-infected patients were co-infected with HCV in different areas of China [6], and the prevalence was 96.6% in IDUs and 92.9% in former paid blood donors (FBD) [7]. "
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