AHV; National Institute for Clinical Excellence. Non-motor symptoms of Parkinson's disease: diagnosis and management

Movement Disorders Unit, Kings College Hospital, Guy's King's and St Thomas' School of Medicine, London, UK.
The Lancet Neurology (Impact Factor: 21.82). 04/2006; 5(3):235-45. DOI: 10.1016/S1474-4422(06)70373-8
Source: PubMed

ABSTRACT The clinical diagnosis of Parkinson's disease rests on the identification of the characteristics related to dopamine deficiency that are a consequence of degeneration of the substantia nigra pars compacta. However, non-dopaminergic and non-motor symptoms are sometimes present before diagnosis and almost inevitably emerge with disease progression. Indeed, non-motor symptoms dominate the clinical picture of advanced Parkinson's disease and contribute to severe disability, impaired quality of life, and shortened life expectancy. By contrast with the dopaminergic symptoms of the disease, for which treatment is available, non-motor symptoms are often poorly recognised and inadequately treated. However, attention is now being focused on the recognition and quantitation of non-motor symptoms, which will form the basis of improved treatments. Some non-motor symptoms, including depression, constipation, pain, genitourinary problems, and sleep disorders, can be improved with available treatments. Other non-motor symptoms can be more refractory and need the introduction of novel non-dopaminergic drugs. Inevitably, the development of treatments that can slow or prevent the progression of Parkinson's disease and its multicentric neurodegeneration provides the best hope of curing non-motor symptoms.

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    • "Alongside motor symptoms, people with PD also experience non-motor symptoms (NMS) such as: pain, drooling; choking/ swallowing difficulties; constipation; bladder dysfunction; cognitive impairment; hallucinations; depression/anxiety; sexual dysfunction; insomnia, which occur from disease onset [8]. Nonmotor symptoms contribute to severe disability, impaired QoL, and institutionalization [9], and can be more troublesome and disabling for the patient than motor complications [10]. Recent work suggests some NMS are treatable using device-aided therapies [11] [12] since they are often dopaminergic in origin. "
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    ABSTRACT: Navigate PD was an educational program established to supplement existing guidelines and provide recommendations on the management of Parkinson's disease (PD) refractory to oral/transdermal therapies. It involved 103 experts from 13 countries overseen by an International Steering Committee (ISC) of 13 movement disorder specialists. The ISC identified 71 clinical questions important for device-aided management of PD. Fifty-six experts responded to a web-based survey, rating 15 questions as 'critically important;' these were refined to 10 questions by the ISC to be addressed through available evidence and expert opinion. Draft guidance was presented at international/national meetings and revised based on feedback. Key take-home points are: • Patients requiring levodopa >5 times daily who have severe, troublesome 'off' periods (>1-2 h/day) despite optimal oral/transdermal levodopa or non-levodopa-based therapies should be referred for specialist assessment even if disease duration is <4 years. • Cognitive decline related to non-motor fluctuations is an indication for device-aided therapies. If cognitive impairment is mild, use deep brain stimulation (DBS) with caution. For patients who have cognitive impairment or dementia, intrajejunal levodopa infusion is considered as both therapeutic and palliative in some countries. Falls are linked to cognitive decline and are likely to become more frequent with device-aided therapies. • Insufficient control of motor complications (or drug-resistant tremor in the case of DBS) are indications for device-aided therapies. Levodopa-carbidopa intestinal gel infusions or subcutaneous apomorphine pump may be considered for patients aged >70 years who have mild or moderate cognitive impairment, severe depression or other contraindications to DBS. Copyright © 2015. Published by Elsevier Ltd.
    Parkinsonism & Related Disorders 07/2015; DOI:10.1016/j.parkreldis.2015.07.020 · 4.13 Impact Factor
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    • "Thus, it may be important for clinicians to consider the complementary effects of dopaminergic and anti-anxiety medications on baseline trait anxiety levels in the management of PD and potentially other movement disorders, especially when considering the secondary influences on gait. Dopamine receptor agonists (such as pramipexole and ropinerole) may be an alternative therapeutic strategy, as dopamine agonists can increase dopamine levels within the limbic system (D3 receptors) and alleviate anxiety symptoms (Chaudhuri et al., 2006; Lemke, 2008; Coakeley et al., 2014), which might also reduce motor symptoms that are worsened by anxiety. Another advantage is that dopamine agonists are argued to reduce motor fluctuations that have been shown to amplify anxiety in PD (Henderson et al., 1992; Witjas et al., 2002; Richard, 2005; Leentjens et al., 2012), and possibly accelerate the 'wearing off' period. "
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    ABSTRACT: In order to understand how dopamine modulates the effect of anxiety on gait, the goal of this study was to use virtual reality to provoke anxiety in PD (in both ON and OFF states) and quantify its effect on gait. Seventeen PD and 20 HC were instructed to walk in a virtual environment in two anxiety-provoking conditions: (i) across a plank that was located on the GROUND; (ii) across an ELEVATED plank. All PD participants completed this in both the ON and OFF states, and then were striated into groups based on baseline trait anxiety scores for further analyses. Anxiety (skin conductance and self-report) and spatiotemporal aspects of gait were measured. Overall, the ELEVATED condition resulted in greater skin conductance levels and self-reported anxiety levels. Additionally, all participants demonstrated slower gait with increased step-to-step variability when crossing the ELEVATED plank compared to the plank on the GROUND. Results showed that dopaminergic treatment selectively improved gait in only the highly anxious PD group, by significantly improving velocity, step length, step time and step-to-step variability specifically when walking across the ELEVATED plank (ON versus OFF comparison). In conclusion, only highly trait anxious PD benefitted from dopaminergic treatment, specifically when walking in the anxiety-provoking environment. Improvements to gait during anxious walking might be a result of dopaminergic medication acting in two ways: 1) improving the basal ganglia's capacity to process information and 2) by reducing the load from anxiety and subsequently making more resources available to effectively process other competing inputs. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    European Journal of Neuroscience 04/2015; DOI:10.1111/ejn.12928 · 3.67 Impact Factor
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    • "Idiopathic Parkinson's disease (PD) is a neurodegenerative illness that involves neurons in the zona compacta of the substantia nigra of the midbrain and other pigmented nuclei [1] [2] [3]. This pathology is associated with a wide range of motor (tremor, stiffness, bradykinesia, postural instability) and nonmotor (depression, cognitive impairments, sleep and mood disorders) symptoms that significantly reduce the quality of life of patients [4] [5]. Impairments of voice and speech (hypokinetic dysarthria) are among the main signs of the disease. "
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    ABSTRACT: Abstract Parkinson's disease (PD) involves impairments of voice and speech (hypokinetic dysarthria). Dysprosody is one of the most common features of PD speech that includes alterations of rhythm and velocity of articulation. The aim of this study is the evaluation of dysprosody patterns in Parkinsonian patients during a sentence repetition task by means of a fully automated tool. Twenty PD patients (14 male and 6 female) and 19 healthy controls (9 male and 10 female) were tested. Results show significant differences between the two groups as far as the time interval between each sentence repetition (Tinter), the percent of speech time with respect to sentence duration (D%) and the Net Speech Rate (NSR – defined as the number of syllables of the sentence divided by the effective speech time) are concerned. In particular, Tinter is larger in PD patients while D% is higher in the control group. These results show that PD patients may exhibit longer pauses between each sentence repetition and a lower percentage of “speech time” during a whole repetition period. Thus, the decrease of D% leads to an increase of NSR. Other acoustic parameters (noise and F0 variability) did not show any significant difference. This study confirms that speech in PD patients is characterized by short rushes followed by unorthodox pauses. These results may lead to the development of a system for the automatic acoustic analysis which could significantly reduce the processing time in particular during pre-processing, that to date is a time-consuming and operator-dependent step especially in case of recordings of long duration.
    Biomedical Signal Processing and Control 03/2015; 17:47 - 54. DOI:10.1016/j.bspc.2014.07.006 · 1.53 Impact Factor
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