Infectious mononucleosis and risk for multiple sclerosis: A meta-analysis

Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
Annals of Neurology (Impact Factor: 11.91). 03/2006; 59(3):499-503. DOI: 10.1002/ana.20820
Source: PubMed

ABSTRACT To characterize the association between infectious mononucleosis (IM), a frequent clinical manifestation of primary Epstein-Barr virus infection after childhood, and the risk for multiple sclerosis (MS).
We conducted a systematic review and meta-analysis of case-control and cohort studies of IM and MS.
The combined relative risk of MS after IM from 14 studies was 2.3 (95% confidence interval, 1.7-3.0; p < 10(-8)). Potential sources of heterogeneity (ie, study design, MS definition, and latitude) barely influenced our results.
We conclude that Epstein-Barr virus infection manifesting as IM in adolescents and young adults is a risk factor for MS.

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