Regulation of aging and age-related disease by DAF-16 and heat-shock factor

Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-2200, USA.
Science (Impact Factor: 31.48). 06/2003; 300(5622):1142-5. DOI: 10.1126/science.1083701
Source: PubMed

ABSTRACT The Caenorhabditis elegans transcription factor HSF-1, which regulates the heat-shock response, also influences aging. Reducing hsf-1 activity accelerates tissue aging and shortens life-span, and we show that hsf-1 overexpression extends lifespan. We find that HSF-1, like the transcription factor DAF-16, is required for daf-2-insulin/IGF-1 receptor mutations to extend life-span. Our findings suggest this is because HSF-1 and DAF-16 together activate expression of specific genes, including genes encoding small heat-shock proteins, which in turn promote longevity. The small heat-shock proteins also delay the onset of polyglutamine-expansion protein aggregation, suggesting that these proteins couple the normal aging process to this type of age-related disease.


Available from: Ao-Lin Hsu, Apr 26, 2015
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