Article

Expression of the onconeural CV2/CRMP5 antigen in thymus and thymoma.

Equipe d'Accueil 3062, Université Jean-Monnet, Saint-Etienne, France.
Journal of Neuroimmunology (impact factor: 2.96). 06/2006; 174(1-2):168-73. DOI:10.1016/j.jneuroim.2006.01.018 pp.168-73
Source: PubMed

ABSTRACT Anti-CV2 antibodies (AB) react with the developmentally regulated neural proteins CRMPs and particularly with CRMP5. They occur with small cell lung cancer (SCLC) and thymoma. SCLCs universally express CRMP5. We investigated the expression of CRMPs in thymoma and thymus. In thymoma, none of the CRMPs were detected by immunohistochemistry in tumorous epithelial cells with specific antibodies including CRMP5 but an antibody reacting with a peptide common to the CRMPs labeled a 66-kDa protein in Western blot of rat brain, thymus, and thymoma extracts. Thus, the normal CRMP5 is probably not expressed by tumorous epithelial cells. These results indicate that the mechanisms leading to CRMP5 autoimmunization are different in SCLC and thymoma.

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Keywords

66-kDa protein
 
Anti-CV2 antibodies
 
CRMP5
 
CRMP5 autoimmunization
 
CRMPs
 
developmentally
 
neural proteins CRMPs
 
normal CRMP5
 
peptide common
 
rat brain
 
SCLC
 
SCLCs
 
small cell lung cancer
 
specific antibodies
 
thymoma
 
thymus
 
tumorous epithelial cells