Article

Personality factors correlate with regional cerebral perfusion.

Department of Neuroimaging, Ground floor, Ruskin Wing, King's College Hospital, Denmark Hill, London SE5 9RS, UK.
NeuroImage (impact factor: 5.89). 07/2006; 31(2):489-95. DOI:10.1016/j.neuroimage.2005.12.048
Source: PubMed

ABSTRACT There is an increasing body of evidence pointing to a neurobiological basis of personality. The purpose of this study was to investigate the biological bases of the major dimensions of Eysenck's and Cloninger's models of personality using a noninvasive magnetic resonance perfusion imaging technique in 30 young, healthy subjects. An unbiased voxel-based analysis was used to identify regions where the regional perfusion demonstrated significant correlation with any of the personality dimensions. Highly significant positive correlations emerged between extraversion and perfusion in the basal ganglia, thalamus, inferior frontal gyrus and cerebellum and between novelty seeking and perfusion in the cerebellum, cuneus and thalamus. Strong negative correlations emerged between psychoticism and perfusion in the basal ganglia and thalamus and between harm avoidance and perfusion in the cerebellar vermis, cuneus and inferior frontal gyrus. These observations suggest that personality traits are strongly associated with resting cerebral perfusion in a variety of cortical and subcortical regions and provide further evidence for the hypothesized neurobiological basis of personality. These results may also have important implications for functional neuroimaging studies, which typically rely on the modulation of cerebral hemodynamics for detection of task-induced activation since personality effects may influence the intersubject variability for both task-related activity and resting cerebral perfusion. This technique also offers a novel approach for the exploration of the neurobiological correlates of human personality.

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Keywords

biological bases
 
cerebral hemodynamics
 
Cloninger's models
 
functional neuroimaging studies
 
healthy subjects
 
hypothesized neurobiological basis
 
increasing body
 
inferior frontal gyrus
 
intersubject variability
 
major dimensions
 
neurobiological basis
 
noninvasive magnetic resonance perfusion imaging technique
 
personality dimensions
 
personality effects
 
regional perfusion
 
resting cerebral perfusion
 
significant correlation
 
significant positive correlations
 
Strong negative correlations
 
unbiased voxel-based analysis