Effects of the etonogestrel-releasing implant Implarion (R) and a nonmedicated intrauterine device on the growth of breast-fed infants

King Chulalongkorn Memorial Hospital, Krung Thep, Bangkok, Thailand
Contraception (Impact Factor: 2.34). 05/2006; 73(4):368-71. DOI: 10.1016/j.contraception.2005.10.010
Source: PubMed


The study objectives were to compare the effects of an etonogestrel-releasing implant (Implanon) and a nonmedicated intrauterine device (IUD) on parameters of lactation in breast-feeding women and on the growth of their breast-fed infants over a 3-year period. Healthy lactating women (28-56 days postpartum) chose either the implant (n=42) or the IUD (n=38). Infant growth during a 3-year follow-up period is reported here. Total duration of breast-feeding coinciding with the mothers' treatment was 421.0 and 423.4 days in the Implanon and IUD groups, respectively. There were no differences between the infant groups in terms of body length, biparietal head circumference and body weight. No abnormalities were reported in psychomotor development or during physical examination. No treatment-related side effects were observed in either group. In conclusion, there were no differences in the growth of breast-fed infants of women treated with Implanon or a nonmedicated IUD. Implanon, therefore, appears to be a safe contraceptive option for breast-feeding women and their infants.

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    • "Importantly, 24-hour milk production and infant growth rates were not different between the two groups. Infants were exposed to the etonogestrel with an initial dose of 19.86 ng/kg/day, equivalent to 1.7% of the maternal dose, during the first month of use, but this dose decreased between months 2 and 4.28 After completion of this trial, researchers followed women and infants over a three-year period to evaluate any differences in long term outcomes.29 Over 80% of subjects in each group completed this follow up. "
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