Article

Type III secretion: what's in a name?

Institut National de la Recherche Agronomique, Centre de Recherche de Clermont-Ferrand-Theix, UR 454, Unité de Microbiologie, F-63122 Saint-Genès Champanelle, France.
Trends in Microbiology (Impact Factor: 9.81). 05/2006; 14(4):157-60. DOI: 10.1016/j.tim.2006.02.009
Source: PubMed

ABSTRACT The term 'type III secretion' has seen widespread use. However, problems persist in nomenclature. We propose that the standard abbreviation for this kind of secretion should be 'T3S' and that 'type III secretion system' should be abbreviated to 'T3SS'. There is also a need for a new terminology to distinguish flagellar and non-flagellar type III secretion systems that reflects their common evolutionary ancestry but does not obscure their distinctive features. Finally, the use of the term 'type III secretion' to cover cytolysin-mediated translocation is to be deprecated because an authentic type III secretion system has already been described in gram-positive bacteria, namely the flagellar protein export apparatus.

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    • "In summary, these data indicate that the protein-specific residues within the amino-termini of FlaA and FlaB affect the level of protein secretion through the flagellum. As previously mentioned, the flagellum is a T3SS used to secrete flagellar structural components as well as effector proteins (Konkel et al., 1999, Konkel et al., 2004, Minamino & Namba, 2004, Desvaux et al., 2006). The mechanisms of T3S protein recognition and export are conserved between classical " injectisome " T3SS and flagellar T3SS, as it has been demonstrated that several proteins can be secreted through both systems. "
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