The diagnostic value of image guided percutaneous fine needle aspiration biopsy in equivocal mediastinal masses
ABSTRACT The aim of this study was to assess the diagnostic value of image guided percutaneous fine needle aspiration (FNA) biopsy in equivocal mediastinal masses.
Sixty-six patients with an equivocal mediastinal mass who underwent FNA biopsy between 1993 and 2003 were eligible for final analysis. The cytological and definitive diagnosis of masses were grouped as primary 22 (33%)-30 (46%) and secondary (metastatic) neoplasms 18 (27%)-18 (27%) and nonneoplastic lesions 20 (30%)-18 (27%) respectively.
The diagnostic accuracy (95% C.I.) of FNA biopsy for primary mediastinal neoplasms, secondary neoplasms and nonneoplastic lesions were found to be 93.3 (83.8-98.2)%, 100 (95.1-100)%, 93.3 (83.8-98.2)%, respectively.
Image guided percutaneous FNA biopsy is a safe and highly accurate diagnostic method for equivocal mediastinal masses.
- SourceAvailable from: bvs.sld.cu
- [Show abstract] [Hide abstract]
ABSTRACT: To describe various approaches of computed tomography (CT)-guided core biopsy and evaluate its ability to obtain adequate tissue for the assessment of mediastinal masses. Between February 2004 and October 2006, 83 percutaneous CT-guided biopsies of mediastinal lesions were performed on 82 patients under local anesthesia. Coaxial needles were used and minimum of 3-4 cores were obtained. Post-biopsy CT scan was performed and patients observed for any complications. Tissue samples were taken to Pathology Department in formalin solution. From the 83 biopsies, adequate tissue for histological diagnosis was obtained in 80 (96%), and the biopsy was considered diagnostic. Of the 80 diagnostic biopsies, 74 biopsy samples were definitive for neoplastic pathology and 6 biopsy samples revealed no evidence of malignancy. There were no major complications. Minor complications were recorded in 5 patients. Percutaneous image-guided core biopsy of mediastinal lesions is an accurate, safe and cost-effective tool for the initial assessment of patients with mediastinal masses.Annals of Thoracic Medicine 02/2008; 3(1):13-7. DOI:10.4103/1817-1737.37948 · 1.34 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Many histologically different tumors and cysts that affect people of all ages arise from the multiple anatomic structures present in the mediastinum. The number of diagnostic possibilities can be narrowed by considering the patient's age, tumor location, the presence or absence of symptoms and signs, the association of a specific systemic disease, radiographic findings, and biochemical markers. Pathologic diagnosis is often required to confirm a presumed diagnosis and to select the optimal treatment modality. A variety of biopsy techniques for obtaining tissue from the mediastinum have been described, including ultrasound-guided endoscopic biopsy, percutaneous image-guided needle biopsy, parasternal anterior mediastinotomy, cervical mediastinoscopy, and video-assisted thoracoscopic surgery. The choice of biopsy technique depends on the localization of the lesion, clinical factors such as the age and the condition of the patient, and the availability of special techniques with the required expert and the equipment.Thoracic Surgery Clinics 03/2009; 19(1):29-35, vi. DOI:10.1016/j.thorsurg.2008.09.001 · 0.77 Impact Factor