Article

Effects of taurine on rat behaviors in three anxiety models

Department of Pharmacology, Shenyang Pharmaceutical University, Box 41, 103 Wenhua Road, 110016 Shenyang, P. R. China.
Pharmacology Biochemistry and Behavior (Impact Factor: 2.82). 03/2006; 83(2):271-6. DOI: 10.1016/j.pbb.2006.02.007
Source: PubMed

ABSTRACT In our previous studies using an elevated plus-maze test in mice, taurine was shown to present an anxiolytic-like effect after single and repeated administration. The aim of the present study was to investigate the anxiolytic and behavioral effects of taurine on rats in the open field, hole-board, and social interaction test compared to the positive control diazepam. Taurine (14, 42, and 126 mg/kg, i.p.) was administered 30 min before the tests. In the social interaction and hole-board tests, taurine (42 mg/kg) significantly increased social interaction time and the number and duration of head-dipping. In the open field test, taurine (126 mg/kg, i.p.) presented anxiolytic-like effects by increasing the number of center entries, time spent in the central area and the anti-thigmotactic score while having no effect on the locomotor activity. Results from these experiments suggest that taurine produces an anxiolytic-like effect in these animal models and may act as a modulator or anti-anxiety agent in the central nervous system.

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    • "Both times of exposure and EtOH concentration were selected based on those described in the literature, which showed alterations on anxiety-like behavioral responses (Mathur and Guo, 2011) and also on distinct neurochemical parameters of this species (Gerlai et al., 2000; Dlugos and Rabin, 2003; Rico et al., 2007; Chatterjee and Gerlai, 2009; Rosemberg et al., 2010a). The acute TAU treatments were performed as described by Rosemberg et al. (2010a) and the concentrations chosen were based on previous studies, varying from 0.33 to 3.2 mM (Wu et al., 2005; Kong et al., 2006; Rosemberg et al., 2010b). TAU solutions were prepared just before the experiments and buffered to pH 7.0 using 0.1 N NaOH. "
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