Article

BRCA1-positive breast cancers in young women from Poland.

Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Połabska 4, 70-115 Szczecin, Poland.
Breast Cancer Research and Treatment (impact factor: 4.43). 09/2006; 99(1):71-6. DOI:10.1007/s10549-006-9182-3 pp.71-6
Source: PubMed

ABSTRACT We identified 4316 unselected incident cases of early-onset breast cancers (<51 ears of age at diagnosis) in 18 Polish hospitals between 1996 and 2003. We were able to obtain a blood sample for DNA analysis from 3472 of these (80.4%). All cases were tested for the presence of three founder mutations in BRCA1. The proportion of cases with a BRCA1 mutation was 5.7%. The hereditary proportions were higher than this for women with breast cancer diagnosed before age 40 (9%), for women with cancer of medullary or atypical medullary histology (28%), for those with bilateral cancer (29%) or with a family history of breast or ovarian cancer (13%). It is reasonable to offer genetic testing to women with early-onset breast cancer in Poland.

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Keywords

18 Polish hospitals
 
4316 unselected incident cases
 
atypical medullary histology
 
bilateral cancer
 
BRCA1 mutation
 
cases
 
DNA analysis
 
early-onset breast cancers
 
family history
 
founder mutations
 
hereditary proportions
 
medullary
 
offer genetic testing
 
women