Cobalt(II) chloride catalyzed one-pot synthesis of α-aminonitriles

Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA.
Beilstein Journal of Organic Chemistry (Impact Factor: 2.76). 02/2005; 1(1):8. DOI: 10.1186/1860-5397-1-8
Source: PubMed


A simple and efficient method has been developed for the synthesis of alpha-aminonitriles by a one-pot three- component condensation of aldehydes, amines, and potassium cyanide in acetonitrile in the presence of a catalytic amount of CoCl2 at room temperature.

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