Can Administration of Potentized Homeopathic Remedy, Arsenicum Album, Alter Antinuclear Antibody (ANA) Titer in People Living in High-Risk Arsenic Contaminated Areas? I. A Correlation with Certain Hematological Parameters

University of Kalyani, Kalyani, West Bengal, India
Evidence-based Complementary and Alternative Medicine (Impact Factor: 1.88). 04/2006; 3(1):99-107. DOI: 10.1093/ecam/nek013
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ABSTRACT To examine whether elevated antinuclear antibody (ANA) titers reported in random human population of arsenic contaminated villages can be reverted to the normal range by administration of a potentized homeopathic drug, Arsenicum album, randomly selected volunteers in two arsenic contaminated villages and one arsenic-free village in West Bengal (India) were periodically tested for their ANA titer as well as various blood parameters in two types of experiments: 'placebo-controlled double blind' experiment for shorter duration and 'uncontrolled verum fed experiment' for longer duration. Positive modulation of ANA titer was observed along with changes in certain relevant hematological parameters, namely total count of red blood cells and white blood cells, packed cell volume, hemoglobin content, erythrocyte sedimentation rate and blood sugar level, mostly within 2 months of drug administration. Thus, Arsenicum album appears to have great potential for ameliorating arsenic induced elevated ANA titer and other hematological toxicities.

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Available from: Philippe Belon, Sep 26, 2015
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    • "Epidemiological and experimental data indicate the diabetogenic role of arsenic (Navas-Acien et al., 2006) and exposure to high level of arsenic in drinking water well above 100 ppb has been associated with an increased risk of diabetes in high arsenic areas of Taiwan and Bangladesh (Lai et al., 1994). In arsenic contaminated areas in West Bengal, India, prevalence of arsenic induced hyperglycemia has also been reported (Belon et al., 2006), necessitating large scale administration of insulin in the management of type 2 diabetes as a last resort for its effective control. But chronic use of insulin has its own set of problems: its cost, development of drug-dependence, and sometimes necessity for increase in dose, for which a strict monitoring and management regimen is required, particularly because of the added risk of a sudden fall in sugar level in those who receive insulin as a conventional add-on therapy along with some other anti-diabetic drug(s). "
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    ABSTRACT: Diabetes is a menacing problem, particularly in inhabitants of groundwater arsenic contaminated area needing new medical approaches. This study examines if PLGA loaded nano-insulin (NIn), administered either intraperitoneally (ip) or through oral route, has a greater cost-effective anti-hyperglycemic potential than that of insulin in chronically arsenite-fed hyperglycaemic mice. The particle size, morphology and zeta potential of nano-insulin using dynamic light scattering method, scanning electronic and atomic force microscopies were determined. The ability of the nano-insulin (NIn) to cross the blood-brain-barrier (BBB) was also checked. Circular dichroic spectroscopic (CD) data of insulin and nano-insulin in presence or absence of arsenic were compared. Several diabetic markers in different groups of experimental and control mice were assessed. The mitochondrial functioning through indices like cytochrome c, pyruvate-kinase, glucokinase, ATP/ADP ratio, mitochondrial membrane potential, cell membrane potential and calcium-ion level was also evaluated. Expressions of the relevant marker proteins and mRNAs like insulin, GLUT2, GLUT4, IRS1, IRS2, UCP2, PI3, PPARγ, CYP1A1, Bcl2, caspase3 and p38 for tracking-down the signaling cascade were also analyzed. Results revealed that ip-injected nano-encapsulated-insulin showed better results; NIn, due to its smaller size, faster mobility, site-specific release, could cross BBB and showed positive modulation in mitochondrial signaling cascades and other downstream signaling molecules in reducing arsenic-induced-hyperglycemia. CD data indicated that nano-insulin had less distorted secondary structure as compared with that of insulin in presence of arsenic. Thus, overall analyses revealed that PLGA nano-insulin showed better efficacy in combating arsenite-induced-hyperglycemia than that of insulin and therefore, has greater potentials for use in nano-encapsulated form.
    Toxicology and Applied Pharmacology 12/2012; 267(1). DOI:10.1016/j.taap.2012.12.018 · 3.71 Impact Factor
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    • "In the attempt to characterize the high-dilution action as a biological phenomenon, several experimental studies have been performed in the last years using cell or animal models [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] or even vegetal models [16] [17] [18] [19] [20], giving experimental and theoretical substrate to the development of agricultural tools using high dilutions of active substances, that is called " agro-homeopathy " . These studies include clinical veterinary research in livestock animals, and the homeopathic medicines point out as possibilities to treat common diseases or serve as zoo technical tools [21] [22] [23] [24] [25]. "
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    ABSTRACT: As little information about the effect of ultra high dilutions of glucocorticoid in reproduction is available in the literature, pregnant female Wistar rats ( N = 12 ) were blindly subcutaneously treated during all gestational and lactation period with: dexamethasone 4 mg/kg diluted into dexamethasone 15 cH (mixed); or dexamethasone 4 mg/kg diluted in water; or dexamethasone 15 cH, or vehicle. Parental generation had body weight, food and water consumption monitored. The F1 generation was monitored regarding to newborn development. No birth occurred in both groups treated with dexamethasone 4 mg/kg. After 60 days from birth, 12 male F1 rats were randomly selected from each remaining group and inoculated subcutaneously with 1% carrageenan into the footpad, for evaluation of inflammatory performance. Edema and histopathology of the footpad were evaluated, using specific staining methods, immunohistochemistry and digital histomorphometry. Mothers treated with mixed dexamethasone presented reduced water consumption. F1 rats born to dexamethasone 15 cH treated females presented significant increase in mast cell degranulation, decrease in monocyte percentage, increase in CD18+ PMN cells, and early expression of ED2 protein, in relation to control. The results show that the exposure of parental generation to highly diluted dexamethasone interferes in inflammation modulation in the F1 generation.
    Evidence-based Complementary and Alternative Medicine 07/2012; 2012(4):710923. DOI:10.1155/2012/710923 · 1.88 Impact Factor
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    • "On the other hand arsenic has been recently proposed as an additional risk factor for diabetes (Silbergeld et al., 2008; Longnecker and Daniels, 2001). According to recent surveys it is found that the occurrence of diabetes is significantly higher in arsenic-endemic villages in Taiwan and India than in the general population (Zimmet, 1982; Wang et al., 1997; Belon et al., 2006). The prevalence of diabetes mellitus was 2-fold higher in these areas than in Taipei City and the Taiwan area in general. "
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    ABSTRACT: Arsenic toxicity induces type 2 diabetes via stress mediated pathway. In this study, we attempt to reveal how sodium arsenite (iAs) could induce stress mediated impaired insulin signaling in mice and if an isolated active fraction of ginger, [6]-gingerol could attenuate the iAs intoxicated hyperglycemic condition of mice and bring about improvement in their impaired insulin signaling. [6]-Gingerol treatment reduced elevated blood glucose level and oxidative stress by enhancing activity of super oxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and GSH. [6]-Gingerol also helped in increasing plasma insulin level, brought down after iAs exposure. iAs treatment to primary cell culture of β-cells and hepatocytes in vitro produced cyto-degenerative effect and accumulated reactive oxygen species (ROS) in pancreatic β-cells and hepatocytes of mice. [6]-Gingerol appeared to inhibit/intervene iAs induced cyto-degeneration of pancreatic β-cells and hepatocytes, helped in scavenging the free radicals. The over-expression of TNFα and IL6 in iAs intoxicated mice was down-regulated by [6]-gingerol treatment. iAs intoxication reduced expression levels of GLUT4, IRS-1, IRS-2, PI3K, AKT, PPARγ signaling molecules; [6]-gingerol mediated its action through enhancing the expressions of these signaling molecules, both at protein and mRNA levels. Thus, our results suggest that [6]-gingerol possesses an anti-hyperglycemic property and can improve impaired insulin signaling in arsenic intoxicated mice.
    Toxicology Letters 01/2012; 210(1):34-43. DOI:10.1016/j.toxlet.2012.01.002 · 3.26 Impact Factor
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