Colon and gastric metastases from a primary signet-ring cell carcinoma of the urinary bladder
ABSTRACT Signet-ring cell carcinoma is a relatively rare neoplasm that rarely occurs in the urinary bladder. We report a case of a 60-year-old man who presented with gross haematuria. Cystoscopy revealed a white sessile tumour of the anterior bladder wall. The histological diagnosis showed a primary signet-ring cell carcinoma of the bladder (T3bN0M0). Eighteen months after radical cystectomy, the patient developed colon and stomach metastases. This case represents the first description of a primary signet-ring cell carcinoma of the urinary bladder with gastrointestinal metastases.
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ABSTRACT: Primary signet ring cell carcinomas (SRCCs) of the bladder and urachus are extremely rare malignancies with only 28 cases of urachal SRCC recorded and bladder SRCC comprising less than 0.1% of bladder malignancies. These rare cases of urothelial SRCC occur largely in men and the disease characteristically presents in patients in their 40s for urachal SRCC and 60s for bladder SRCC. Despite the rarity of the diagnosis, a knowledge of the natural history and management of urothelial SRCC may be valuable as the illness has a number of important differences from conventional bladder TCC. The characteristic pathological findings of sub-mucosal infiltration and spread are often reflected in the clinical presentation and progress of the disease. Bladder SRCC is frequently characterised by a late presentation at an advanced stage, with dysuria the most frequent presenting symptom whilst haematuria is relatively rare. Metastatic spread can occur with retroperitoneal disease that can be difficult to visualise on imaging and can lead to ureteric or small bowel obstruction. As a result of their rarity there is no structured clinical research in urothelial SRCC and the optimal management of early and advanced cases of this rare tumour is unknown. A number of differing chemotherapy regimens have been reported for advanced disease in various case reports and series with variable responses and generally modest benefits.British Journal of Medical and Surgical Urology 01/2011; 4(1):2-7. DOI:10.1016/j.bjmsu.2010.02.010
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ABSTRACT: Signet ring cell variant of mucinous adenocarcinoma of the urinary bladder is an exceptionally rare urologic malignancy, generally felt to be resistant to chemotherapy and radiotherapy. We describe a case of this malignancy with unusual sites of metastasis and an unexpectedly good response to treatment.Canadian Urological Association journal = Journal de l'Association des urologues du Canada 02/2012; 6(1):E15-9. DOI:10.5489/cuaj.11019 · 1.92 Impact Factor