Article

[The changes of advanced glycation end products in a rat liver fibrosis model and the interventional effect of aminoguanidin].

Department of Gastroenterology, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China.
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 03/2006; 14(3):178-82. pp.178-82
Source: PubMed

ABSTRACT To study the changes of advanced glycation end products (AGEs) in different phases of a rat liver fibrosis model induced by CCl4, and the interventional effect of aminoguanidin (AG).
Fifty-four SD rats were divided into three groups: a control group, a CCl4 model group and an intervention group. Their blood serum AGEs and hyaluronic acid (HA) and AGEs in their liver homogenates were measured. These measurements were correlatively assessed to the degrees of liver fibrosis at different phases of the rat model before and after the intervention with aminoguanidin.
The content of AGEs in their blood sera and liver homogenates, and the level of blood serum HA, and the score of liver fibrosis degree at week 12 in our rat liver fibrosis mode groups were significantly higher than those in the control group (P < 0.01). In the intervention group with aminoguanidin, these figures were lower than those in the liver fibrosis model group (P < 0.05). The content of AGEs in their blood sera and liver homogenates had a linear correlation with the level of HA in their blood sera.
The contents of AGEs in their blood sera and liver homogenates were increased in the late phase of our rat liver fibrosis model. To some extent, the level of AGEs may reflect the fibrosis degree of the rat livers. Aminoguanidin has an interventional effect in our CCl4 induced rat liver fibrosis model.

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Keywords

blood sera
 
blood serum
 
blood serum AGEs
 
CCl4 induced rat liver fibrosis model
 
CCl4 model group
 
different phases
 
fibrosis degree
 
glycation end products
 
hyaluronic acid
 
interventional effect
 
linear correlation
 
liver fibrosis degree
 
liver fibrosis model group
 
liver homogenates
 
rat liver fibrosis mode groups
 
rat liver fibrosis model
 
rat liver fibrosis model induced
 
rat livers
 
rat model
 
SD rats
 

Fu-Sheng Gao