Magnesium and neoplasia: from carcinogenesis to tumor growth and progression or treatment.

Istituto di Patologia generale, e Centro di Ricerche Oncologiche Giovanni XXIII, Facoltà di Medicina, Università Cattolica del Sacro Cuore, Largo F. Vito, 100168 Rome, Italy.
Archives of Biochemistry and Biophysics (Impact Factor: 3.04). 03/2007; 458(1):24-32. DOI: 10.1016/
Source: PubMed

ABSTRACT Magnesium is involved in a wide range of biochemical reactions that are crucial to cell proliferation, differentiation, angiogenesis, and apoptosis. Changes in magnesium availability have been shown to influence biological responses of immuno-inflammatory cells. Equally plausible seems to be an involvement of magnesium in the multistep and interconnected processes that lead to tumor formation and development; however, the "how" and "when" of such an involvement remain to be defined. Here, we reviewed in vitro and in vivo data that indicated a role for magnesium in many biological and clinical aspects of cancer (from neoplastic transformation to tumor growth and progression or pharmacologic treatment). In adopting this approach we went through a full circle from molecular aspects to observational or epidemiological studies that could reconcile in a unifying picture the otherwise fragmentary or puzzling data currently available on the role of magnesium in cancer.

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