Magnesium and neoplasia: from carcinogenesis to tumor growth and progression or treatment.
ABSTRACT Magnesium is involved in a wide range of biochemical reactions that are crucial to cell proliferation, differentiation, angiogenesis, and apoptosis. Changes in magnesium availability have been shown to influence biological responses of immuno-inflammatory cells. Equally plausible seems to be an involvement of magnesium in the multistep and interconnected processes that lead to tumor formation and development; however, the "how" and "when" of such an involvement remain to be defined. Here, we reviewed in vitro and in vivo data that indicated a role for magnesium in many biological and clinical aspects of cancer (from neoplastic transformation to tumor growth and progression or pharmacologic treatment). In adopting this approach we went through a full circle from molecular aspects to observational or epidemiological studies that could reconcile in a unifying picture the otherwise fragmentary or puzzling data currently available on the role of magnesium in cancer.
- SourceAvailable from: Slavica Dodig[Show abstract] [Hide abstract]
ABSTRACT: Magnesium is an essential biological cation, participating in whole spectrum of biological functions. It is an irreplaceable factor for more than 300 enzymatic reactions, including those that use ATP as chemical energy source. Only about 1% of whole body magnesium is present in plasma. Normal plasma concentrations are in a range: 0.75-1.00 mmol/L. Concentrations lower or higher than in this interval are called hypomagnesemia and hypermagnesemia, respectively. Those are life treathening conditions. Hypomagnesemia requires quick i.v. supplementation with magnesium cation. In addition to hypoamgnesemia, we are nowadays aware of a common “invisible” deficit of magnesium in tissues. This is a result of changing nutrition habits causing an insufficient recommended daily uptake (>300mg daily). Large clinical studies have shown that magnesium status is negatively correlated with incidence and severity of diabetes type 2, metabolic syndrome, hypertension and some arrhythmias. Therefore, food supplementation with magnesium is one of positive therapeutic or prevention options. Future larger clinical studies are expected to provide information on usefulness of supplementation in some other common diseases and syndromes (e.g. migraine, fibromyalgia, coronary artery disease, chronic fatigue syndrome).Rad - Medical Sciences. 11/2013; 39:47-68.
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ABSTRACT: Adequate mineral intake is important for the maintenance of bone health, cellular function and general metabolism, and possibly in the aetiology of cancer and other chronic diseases. This study aimed at investigating variation in intakes of selected minerals across 10 European countries participating in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Nutrient intakes for 36 034 subjects, aged between 35 and 74 years, in 27 centres were obtained using standardized 24-h dietary recall software (EPIC-SOFT). Mean intakes of calcium, phosphorus, magnesium, iron and potassium were calculated by centre and weighted by season and day of the week and were also stratified by age group. The contribution of food groups to total nutrient intake was calculated. There was clear geographical variability in intakes, with differences ranging from 35% for magnesium to 90% for iron in men and 36% for potassium to 75% for calcium in women, and a twofold difference in sources of haem iron (meat and fish). There was a geographical gradient in iron intake, with higher intakes in Southern than in Northern Europe and also around a twofold north-south gradient in the contribution of fruits and vegetables to potassium intake. Compared with reference intakes, the majority of age groups and centres had intakes above the recommended levels. Dairy foods and products contributed the most to calcium and phosphorus intake in almost all centres. Cereals and cereal products contributed the most to magnesium and iron intakes, except in Greece and Germany. Intakes of minerals vary substantially throughout Europe, with some geographical variability in their food sources.European journal of clinical nutrition 11/2009; 63 Suppl 4:S101-21. · 3.07 Impact Factor
Conference Paper: Performance of AMC scheme with cluster allocation in OFDM system[Show abstract] [Hide abstract]
ABSTRACT: To achieve high-bit-rate transmission in a mobile communication system, adaptive modulation and coding (AMC) having lots of variation levels in accordance with fading channel variation is a promising technique. In this paper, we compare the performance of AMC methods with cluster in an OFDM system. The AMC schemes applied into each cluster or cluster group are selected by the minimum or the average SNR value. It is important to compare the simulation result by different cluster patterns because AMC performance can be varied according to the number and position of the cluster. It is shown by computer simulation that the AMC method outperforms the fixed modulation one in terms of bandwidth efficiency and its performance can be determined by the position and number of clusters. Also, the AMC scheme with average SNR shows better the outage and bandwidth efficiency performance than the scheme having minimum SNR value.Vehicular Technology Conference, 2004. VTC 2004-Spring. 2004 IEEE 59th; 06/2004