Magnesium and neoplasia: From carcinogenesis to tumor growth and progression or treatment
ABSTRACT Magnesium is involved in a wide range of biochemical reactions that are crucial to cell proliferation, differentiation, angiogenesis, and apoptosis. Changes in magnesium availability have been shown to influence biological responses of immuno-inflammatory cells. Equally plausible seems to be an involvement of magnesium in the multistep and interconnected processes that lead to tumor formation and development; however, the "how" and "when" of such an involvement remain to be defined. Here, we reviewed in vitro and in vivo data that indicated a role for magnesium in many biological and clinical aspects of cancer (from neoplastic transformation to tumor growth and progression or pharmacologic treatment). In adopting this approach we went through a full circle from molecular aspects to observational or epidemiological studies that could reconcile in a unifying picture the otherwise fragmentary or puzzling data currently available on the role of magnesium in cancer.
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ABSTRACT: In order to verify the previously suggested mechanism of anticancer activity of some dimeric indazole derivatives basing on the adhesion (or intercalation) to DNA, a simulation of the interactions of 5-(3,5-dimethyl-1H-pyrazol-1-yl)-3-[(4-methylphenyl)sulfonyl]-1H-indazole with guanosine, adenosine, thymidine, cytidine, and DNA was carried out computationally at the DFT level and analyzed within ONIOM approaches. Moreover, a similar simulation was executed for a DNA fragment containing the above bases. The theoretical studies have shown that the interactions may involve both strong and weak hydrogen bonding arising between the DNA bases nitrogen atoms and the tosyl oxygen and pyrazole nitrogen atoms, as well as aromatic carbons of the studied indazole derivative.Computational and Theoretical Chemistry 05/2015; 1059(1):45-50. DOI:10.1016/j.comptc.2015.02.013 · 1.37 Impact Factor
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ABSTRACT: Adequate mineral intake is important for the maintenance of bone health, cellular function and general metabolism, and possibly in the aetiology of cancer and other chronic diseases. This study aimed at investigating variation in intakes of selected minerals across 10 European countries participating in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Nutrient intakes for 36 034 subjects, aged between 35 and 74 years, in 27 centres were obtained using standardized 24-h dietary recall software (EPIC-SOFT). Mean intakes of calcium, phosphorus, magnesium, iron and potassium were calculated by centre and weighted by season and day of the week and were also stratified by age group. The contribution of food groups to total nutrient intake was calculated. There was clear geographical variability in intakes, with differences ranging from 35% for magnesium to 90% for iron in men and 36% for potassium to 75% for calcium in women, and a twofold difference in sources of haem iron (meat and fish). There was a geographical gradient in iron intake, with higher intakes in Southern than in Northern Europe and also around a twofold north-south gradient in the contribution of fruits and vegetables to potassium intake. Compared with reference intakes, the majority of age groups and centres had intakes above the recommended levels. Dairy foods and products contributed the most to calcium and phosphorus intake in almost all centres. Cereals and cereal products contributed the most to magnesium and iron intakes, except in Greece and Germany. Intakes of minerals vary substantially throughout Europe, with some geographical variability in their food sources.European journal of clinical nutrition 11/2009; 63 Suppl 4:S101-21. DOI:10.1038/ejcn.2009.77 · 2.95 Impact Factor
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ABSTRACT: Cancer remains one of the most difficult and elusive disorders to prevent and treat, despite great efforts in research and treatment over the last 30 years. Researchers have tried to understand the pathogenesis of cancer by discovering the single cellular mechanism or pathway derived from a genetic mutation. There are limited efforts made toward discovering a unified concept of cancer. We propose a neuro-bioenergetic concept of cancer pathogenesis based on the central mechanism of cellular hyperexcitability via inducible overexpression of voltage-gated ion channels, ligand-gated channels and neurotransmitters. Exploration of this concept could lead to a better understanding of the cause of cancer as well as developing more effective and specific strategies toward cancer prevention and treatment.Medical Hypotheses 02/2007; 68(4):832-43. DOI:10.1016/j.mehy.2006.09.005 · 1.15 Impact Factor