Magnesium and neoplasia: From carcinogenesis to tumor growth and progression or treatment
ABSTRACT Magnesium is involved in a wide range of biochemical reactions that are crucial to cell proliferation, differentiation, angiogenesis, and apoptosis. Changes in magnesium availability have been shown to influence biological responses of immuno-inflammatory cells. Equally plausible seems to be an involvement of magnesium in the multistep and interconnected processes that lead to tumor formation and development; however, the "how" and "when" of such an involvement remain to be defined. Here, we reviewed in vitro and in vivo data that indicated a role for magnesium in many biological and clinical aspects of cancer (from neoplastic transformation to tumor growth and progression or pharmacologic treatment). In adopting this approach we went through a full circle from molecular aspects to observational or epidemiological studies that could reconcile in a unifying picture the otherwise fragmentary or puzzling data currently available on the role of magnesium in cancer.
SourceAvailable from: Jacek Kujawski[Show abstract] [Hide abstract]
ABSTRACT: In order to verify the previously suggested mechanism of anticancer activity of some dimeric indazole derivatives basing on the adhesion (or intercalation) to DNA, a simulation of the interactions of 5-(3,5-dimethyl-1H-pyrazol-1-yl)-3-[(4-methylphenyl)sulfonyl]-1H-indazole with guanosine, adenosine, thymidine, cytidine, and DNA was carried out computationally at the DFT level and analyzed within ONIOM approaches. Moreover, a similar simulation was executed for a DNA fragment containing the above bases. The theoretical studies have shown that the interactions may involve both strong and weak hydrogen bonding arising between the DNA bases nitrogen atoms and the tosyl oxygen and pyrazole nitrogen atoms, as well as aromatic carbons of the studied indazole derivative.Computational and Theoretical Chemistry 05/2015; 1059(1):45-50. DOI:10.1016/j.comptc.2015.02.013 · 1.37 Impact Factor
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ABSTRACT: Brine mineral water(BMW) has recently gained attention as a new water resource due to its biological activities. In this study, BMW from the Geumjin area(Gangneung-city, Korea) was evaluated for its growth inhibition, anti-metastasis and anti-angiogenesis activity against cancer cells. The in vitro cytotoxicity was measured by CCK assay, and the anti-metastasis activity was estimated by lung metastasis in vivo. The in vitro incubation of mouse splenic cells with BMW that had been diluted more than 4-fold showed no effect on the cell growth when compared to a control group. Additionally, BMW inhibited the growth of the EL-4, L5178Y-R and colon26-M3.1 cancer cell lines in a dose-dependent manner. In vivo evaluation of the anti-metastasis activity of BMW in BALB/c mice inoculated with the colon26-M3.1 cell line revealed dose-dependent inhibition in response to treatment with samples that were diluted by up to 9 times. Finally, treatment with BMW effectively suppressed the growth of vascular endothelial growth factor(VEGF) added human umbilical vein endothelial cells. Overall, these results suggest that BMW has anti-cancer activity.01/2009; 22(4).
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ABSTRACT: Breast cancer is one of the most common cancer and remains the leading cause of cancer-related deaths in women. There is increasing evidence suggesting that TRPM7 plays a pivotal role in breast cancer progression and metastasis. In this study, a case-control study was carried out to investigate the effects of SNPs in TRPM7 genes in the development of breast cancer in Han Population of Northeast China. A total of six SNPs (rs8042919, rs4775899, rs11635825, rs7173321, rs616256, and rs11070795) were chosen and genotyped. Genotypes were analyzed using a single-base primer extension assay. Chi-square (χ (2)) test was used to analyze statistical difference between control and patient groups in genotype and allele frequencies. The genotype-specific risks and allele frequencies of haplotypes in breast cancer patients and controls were estimated by OR and 95 % confidence intervals. The G allele of rs8042919 was associated with a reduced disease risk. The G allele of rs7173321 and particularly its homozygous GG genotype are associated with an increased breast cancer risk. Two of the TRPM7 SNPs (rs8042919 and rs7173321) are associated with breast cancer patients in Han Population of Northeast China.Medical Oncology 07/2014; 31(7):51. DOI:10.1007/s12032-014-0051-3 · 2.06 Impact Factor