Recurrent central nervous system blastomycosis in an immunocompetent child treated successfully with sequential liposomal amphotericin B and voriconazole.

Division of Pediatric Hematology/Oncology, Children's National Medical Center, Washington, DC, USA.
The Pediatric Infectious Disease Journal (Impact Factor: 3.14). 05/2006; 25(4):377-9. DOI: 10.1097/01.inf.0000207475.89745.51
Source: PubMed

ABSTRACT Central nervous system involvement in infection with Blastomyces dermatitidis is uncommon, except in immunocompromised patients. We report a case of central nervous system blastomycosis occurring 18 months after treatment of pulmonary blastomycosis in an immunocompetent child. Our patient was successfully treated sequentially with liposomal amphotericin B followed by oral voriconazole without need for surgical resection.

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