Article

A case of scrapie in a sheep carrying the lysine-171 allele of the prion protein gene.

CEA--Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Torino, Italy.
Archives of Virology (impact factor: 2.11). 10/2006; 151(9):1875-80. DOI:10.1007/s00705-006-0748-5
Source: PubMed

ABSTRACT Susceptibility to scrapie in sheep depends on the host PrP genotype. No data about the linkage of the rare ARK allele to differential scrapie susceptibility are currently available. Several tissues isolated from sheep from an Italian scrapie outbreak and carrying the ARK allele were examined for the presence of the pathological prion protein. A weak positivity was detected only by Western blot in the brainstem of one ARK/ARH sheep. This result shows that the ARK allele does not confer full resistance against scrapie and that the allele needs to be studied further before it can be considered for breeding purposes.

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Keywords

ARK allele
 
ARK/ARH sheep
 
differential scrapie susceptibility
 
host PrP genotype
 
Italian scrapie outbreak
 
linkage
 
pathological prion protein
 
purposes
 
rare ARK allele
 
scrapie
 
tissues
 
Western blot