Article

Resistoflavine, cytotoxic compound from a marine actinomycete, Streptomyces chibaensis AUBN1/7.

School of Pharmacy, International Medical University, Sesama Center, Plaza, Komanwel, Bukit jalil, 57000 Kuala Lumpur, Malaysia.
Microbiological Research (impact factor: 2.31). 02/2007; 162(4):322-7. DOI:10.1016/j.micres.2006.01.012 pp.322-7
Source: PubMed

ABSTRACT In our systematic screening programme for marine actinomycetes, a bioactive Streptomycete was isolated from marine sediment samples of Bay of Bengal, India. The taxonomic studies indicated that the isolate belongs to Streptomyces chibaensis and it was designated as S. chibaensis AUBN1/7. The isolate yielded a cytotoxic compound. It was obtained by solvent extraction followed by the chromatographic purification. Based on the spectral data of the pure compound, it was identified as quinone-related antibiotic, resistoflavine (1). It showed a potent cytotoxic activity against cell lines viz. HMO2 (Gastric adenocarcinoma) and HePG2 (Hepatic carcinoma) in vitro and also exhibited weak antibacterial activities against Gram-positive and Gram-negative bacteria.

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Keywords

Bengal
 
cell lines viz
 
exhibited weak antibacterial activities
 
Gram-negative bacteria
 
Hepatic carcinoma
 
marine actinomycetes
 
marine sediment samples
 
potent cytotoxic activity
 
quinone-related antibiotic
 
S. chibaensis AUBN1/7
 
spectral data
 
Streptomyces chibaensis
 
taxonomic studies