Gingival crevicular fluid leptin levels in periodontitis patients with long-term and heavy smoking

Department of Periodontology, Faculty of Dentistry, Süleyman Demirel University, Isparta, Turkey.
Journal of Periodontology (Impact Factor: 2.57). 05/2006; 77(4):634-40. DOI: 10.1902/jop.2006.050277
Source: PubMed

ABSTRACT The aim of the present study was to evaluate gingival crevicular fluid (GCF) leptin levels and the influence of long-term and heavy smoking on GCF leptin levels in patients with chronic periodontitis.
In this study, 143 individuals were divided into three groups: non-smokers (NS), smokers (S), and control (C). Three subgroups of NS and S were grouped as follows: a) probing depth (PD) <or=3 mm; b) PD = 4 to 5 mm; and c) PD >5 mm. For each patient, PD, gingival index (GI), plaque index (PI), gingival bleeding time index (GBTI), and clinical attachment level (CAL) values were recorded. The GCF leptin levels obtained from sampling sites were determined by using enzyme-linked immunosorbent assay kits.
The GCF leptin levels were found significantly lower in the a and b subgroups in the S group than those in the NS group (P <0.05). The inflammatory markers GI and GBTI showed significant correlations with leptin in NS (P <0.05).
Our results suggest that higher leptin GCF levels in healthy sites in periodontitis patients may play a protective role in periodontal disease. Further studies are needed to determine the cellular origin of the leptin in the gingiva and the effect of plasma leptin levels on GCF leptin concentrations.

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    • "It has been suggested that leptin orchestrates the immune host response by enhancing cytokine production and phagocytosis by macrophages (Fantuzzi & Faggioni 2000, Sánchez-Margalet et al. 2003a,b, Fernández-Riejos et al. 2010). The presence of leptin has been reported both in healthy and inflamed gingival tissues (Johnson & Serio 2001), in gingival crevicular fluid (Bozkurt et al. 2006, Karthikeyan & Pradeep 2007a,b, Dilsiza et al. 2010) and in human chronic periapical lesions (Haghighi et al. 2010). Elevated serum leptin concentration has been associated with increased chronic periodontitis (Gundala et al. 2012). "
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    Japanese Dental Science Review 08/2010; 46(2). DOI:10.1016/j.jdsr.2010.01.001
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    • "A decreasing leptin level in GCF and gingival tissue is associated with a more deteriorated periodontal status (Johnson and Serio, 2001), and smokers also show reduced GCF leptin levels (Bozkurt et al., 2006), suggesting a protective role of leptin for the periodontium. The relationship between GCF and serum levels of leptin has been recently reported (Karthikeyan and Pradeep, 2007a,b). "
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