Zasloff MFighting infections with vitamin D. Nat Med 12:388-90

Nature Medicine (Impact Factor: 27.36). 05/2006; 12(4):388-90. DOI: 10.1038/nm0406-388
Source: PubMed


Sunlight can treat tuberculosis, a phenomenon observed more than a century ago. The mechanism now becomes more clear, and it involves induction of a microbe-fighting peptide by vitamin D.

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    • "Recent evidence suggested that vitamin D has a protective effect against a variety of diseases, including multiple sclerosis (Kimball, Ursell, O'Connor, & Vieth, 2007; Mahon, Gordon, Cruz, Cosman, & Cantorna, 2003; Munger, Levin, Hollis, Howard, & Ascherio, 2006), diabetes (Casteels et al., 1998; Chiu, Chu, Go, & Saad, 2004; Hypp€ onen, L€ a€ ar€ a, Reunanen, J€ arvelin, & Virtanen, 2001), cardiovascular disease (Lind et al., 1995; Wang et al., 2008), microbial infections (Liu et al., 2006; Martineau et al., 2007; Zasloff, 2006), metabolic syndrome, hypertension, bone diseases and "
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    ABSTRACT: Vitamin D is a fat-soluble regulatory vitamin maintaining blood calcium and phosphorus concentrations within a narrow physiological range. Binding to an appropriate delivery system can enhance vitamin D3 solubility, simplify its transport, protect it from degradation and increase its bioavailability. Alpha-lactalbumin as a milk protein is a good candidate for a vitamin encapsulation. Binding properties and conformational change of bovine apo alpha-lactalbumin upon interaction with vitamin D3 were investigated by calorimetry, spectroscopy and by molecular docking. Tryptophan fluorescence quenching indicates that the protein conformation changes in the presence of vitamin D3. However, according to far UV CD results, the secondary structure of the protein was altered in the presence of vitamin D3. The molecular modeling showed that Van der Waals interactions, hydrogen bond and hydrophobic interactions play a major role in the binding of vitamin D3 to the alpha-lactalbumin hydrophobic pocket. The particle size of alpha-lactalbumin and vitamin D3 complex is much larger than the native protein. Surprisingly, in the presence of vitamin D3, the thermal stability of the protein decreases. The binding constant and standard Gibbs free energy change (ΔG°) of binding vitamin D3 to the protein obtained from ITC are 3.66 × 105 M−1 and −7.6 kcal mol−1, respectively, what agrees with results obtained by measurement of fluorescence and by molecular docking. The formed complex is a suitable candidate in order to enrich the low-fat food and non-alcohol drinks. According to the results, alpha-lactalbumin can be introduced suitable carrier for vitamin D3.
    Food Hydrocolloids 03/2015; 45:124-131. DOI:10.1016/j.foodhyd.2014.10.017 · 4.09 Impact Factor
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    • "The vitamin undergoes two consecutive hydroxylations, one in the liver to 25(OH)D (the inactive form of vitamin D) and the other in the kidneys to 1,25(OH)D, its active form, by the enzyme 1a hydroxylase [3] [4]. Studies have demonstrated a role of vitamin D in enhanced eradication of intracellular pathogens like Mycobacterium tuberculosis [5], killing of a number of antibiotic-resistant bacteria , viruses and Chlamydia [6] [7] and vitamin D deficiency may contribute to chronic respiratory infection and airway colonization [8]. Different lines of evidence also support a role of vitamin D in skeletal muscle health. "
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    ABSTRACT: Vitamin D deficiency is prevalent among patients with chronic obstructive pulmonary disease (COPD) and comes to be more frequent with increased disease severity. We aimed to assess the role of vitamin D supplementation in patients with severe COPD.
    01/2015; 357(2). DOI:10.1016/j.ejcdt.2015.01.002
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    • "Vitamin A and Vitamin D were given to tuberculosis patients in the form of cod liver oil since time immemorial [71] [72]. Deficiency of Vitamin A and Vitamin D has been linked to susceptibility to infections and their role in protective immunity is well proven [71] [72]. Recently, the biologically active form of Vitamin A has been shown to inhibit the growth of virulent M. tuberculosis in macrophages [73] [74]. "
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    ABSTRACT: Tuberculosis is continuing as a problem of mankind. With evolution, MDR and XDR forms of tuberculosis have emerged from drug sensitive strain. MDR and XDR strains are resistant to most of the antibiotics, making the management more difficult. BCG vaccine is not providing complete protection against tuberculosis. Therefore new infections are spreading at a tremendous rate. At the present moment there is experimental evidence to believe that Vitamin A and Vitamin D has anti-mycobacterial property. It is in this context, we have hypothesized a host based approach using the above vitamins that can cause possible prevention and cure of tuberculosis with minimal chance of resistance or toxicity.
    Medical Hypotheses 01/2015; 84(3). DOI:10.1016/j.mehy.2014.12.022 · 1.07 Impact Factor
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