Discovery of Indole-Containing Tetracycles as a New Scaffold for Androgen Receptor Ligands.

Drug Discovery, Johnson & Johnson Pharmaceutical Research and Development, LLC, 1000 Route 202, Raritan, NJ 08869, USA.
Bioorganic & Medicinal Chemistry Letters (Impact Factor: 2.42). 07/2006; 16(12):3233-7. DOI: 10.1016/j.bmcl.2006.03.047
Source: PubMed


A novel series of tetracyclic indoles have been designed, synthesized and evaluated as androgen receptor (AR) ligands. Studies of structure-activity relationships (SARs) were investigated, which led to some compounds in this series as strong binders to androgen receptors.

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