Article

Structure-activity studies of oxazolidinone analogs as RNA-binding agents.

Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, USA.
Bioorganic & Medicinal Chemistry Letters (Impact Factor: 2.34). 08/2006; 16(13):3600-4. DOI: 10.1016/j.bmcl.2006.03.068
Source: PubMed

ABSTRACT We have synthesized and tested a series of novel 3,4,5-tri- and 4,5-disubstituted oxazolidinones for their ability to bind two structurally related T box antiterminator model RNAs. We have found that optimal binding selectivity is found in a small group of 4,5-disubstituted oxazolidinones.

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