Obsessive-compulsive disorder: strategies for using CBT and pharmacotherapy.
Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.The Journal of family practice (Impact Factor: 0.74). 05/2006; 55(4):329-33.
Personality and Mental Health 07/2008; 2(3):192-200. DOI:10.1002/pmh.42 · 1.10 Impact Factor
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ABSTRACT: Two experiments examined probiotic pretreatment (Lactobacillus rhamnosus GG) on obsessive-compulsive disorder (OCD)-like behavior induction by RU 24969 in BALB/cJ house mice. In the first experiment, two groups were defined by their daily pretreatment by oral gavage of either (a) L. rhamnosus (1×10 CFU/day) or (b) the saline vehicle. Both a 2- and 4-week probiotic pretreatment attenuated OCD-like behavior induction (increased perseverative open-field locomotion, stereotypic turning, and marble burying) relative to saline pretreatment. Experiment 2 re-examined the 2-week probiotic pretreatment while also comparing it to a 4-week fluoxetine pretreatment. Again, groups were defined by daily pretreatment of either (a) L. rhamnosus for 2 weeks, (b) the saline vehicle for 2 weeks, or (c) fluoxetine (10 mg/kg) for 4 weeks. Pretreatment by either L. rhamnosus or fluoxetine blocked the induction of OCD-like behavior compared with saline pretreatment. Thus the 2-week probiotic pretreatment was again effective. Although side effects of fluoxetine or L. rhamnosus on androgen-dependent behaviors could not be demonstrated, L. rhamnosus treatment appeared comparable to fluoxetine treatment in attenuating mouse OCD-like behaviors.Behavioural pharmacology 11/2013; DOI:10.1097/FBP.0000000000000013 · 2.19 Impact Factor
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ABSTRACT: Accession Number: 2013-24148-005. First Author & Affiliation: Kullgard, Niclas; Department of Behavioral Sciences and Learning, Linköping University, Linköping, Sweden. Release Date: 20130729. Publication Type: Journal, (0100); Peer Reviewed Journal, (0110); . Media Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Obsessive Compulsive Disorder; Symptoms. Minor Descriptor: Reflectiveness. Classification: Neuroses & Anxiety Disorders (3215) . Population: Human (10); Male (30); Female (40); . Age Group: Adulthood (18 yrs & older) (300) Young Adulthood (18-29 yrs) (320) Thirties (30-39 yrs) (340) Middle Age (40-64 yrs) (360) . Tests & Measures: Reflective Function Scale; Symptom-Specific Reflective Function Scale; Yale-Brown Obsessive Compulsive Scale; Adult Attachment Interview; . Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y.. Page Count: 16.. Issue Publication Date: Jun, 2013. Publication History: Accepted Date:Psychoanalytic Psychotherapy 06/2013; 27(2):154-169. DOI:10.1080/02668734.2013.795909
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