Article

The effect of opioids on the development of postoperative intra-abdominal adhesions.

Department of Surgery, Kungälv Hospital, Kungälv, Sweden.
Digestive Diseases and Sciences (impact factor: 2.12). 04/2006; 51(3):560-5. DOI:10.1007/s10620-006-3170-7 pp.560-5
Source: PubMed

ABSTRACT People addicted to opium rarely develop intra-abdominal adhesions after abdominal surgery. We aimed to evaluate the effect of opium or morphine on preventing postoperative adhesions in rats. Sixty-three rats were randomly divided into a control group, opium-addicted group, and morphine-addicted group in a double-blind study. Drug dependency was checked by using naloxone. Animals were then operated on and the cecum was abraded. At reoperation 3 weeks later the magnitude of adhesions was evaluated by a scoring system. There was a significant difference between the control, opium-addicted, and morphine-addicted groups with regard to the length (P < .001), thickness (P < .05), and severity of adhesions (P < .05). Opium or morphine reduces the severity of postoperative adhesions. Elucidation of the opioid receptor(s) involved in this process would enable the use of selective ligands and offer a pharmacologic strategy in preventing adhesion formation.

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Keywords

abdominal surgery
 
adhesion formation
 
cecum
 
double-blind study
 
Drug dependency
 
intra-abdominal adhesions
 
naloxone
 
opioid receptor(s)
 
opium
 
opium-addicted
 
opium-addicted group
 
People addicted
 
pharmacologic strategy
 
postoperative adhesions
 
reoperation 3 weeks
 
scoring system
 
selective ligands