Blood volume and haemoglobin oxygen content changes in human bone marrow during orthostatic stress.

D├ępartement de Neurosciences Fondamentales, University of Geneva, Switzerland.
Journal of PHYSIOLOGICAL ANTHROPOLOGY (Impact Factor: 1.16). 02/2006; 25(1):1-6. DOI: 10.2114/jpa2.25.1
Source: PubMed

ABSTRACT The interest in, and the need for effective measures to be used in screening, diagnosis, and the follow-up of skeletal pathologies is growing markedly. This paper proposes a completely new and non-invasive technique allowing the study of the human tibia bone marrow (BM) haemodynamics with a time resolution of 1 s. The technique, based on near infrared spectroscopy, is sensitive enough to allow the detection of BM blood volume and/or oxygen saturation changes during orthostatic variations imposed by a tilt bed. An increase in the slope of the bed of 15 degrees is sufficient to detect this phenomenon. The ability to study the possible presence of a neural control of BM haemodynamics is also discussed. No other existing technique currently allows one to obtain the proposed results and this approach might open up a new field of study related to human BM physiology.

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