Bladder cancer and mate consumption in Argentina: A case-control study

School of Public Health, University of California, Berkeley, CA 94720-7360, USA.
Cancer Letters (Impact Factor: 5.62). 03/2007; 246(1-2):268-73. DOI: 10.1016/j.canlet.2006.03.005
Source: PubMed


Mate is a 'tea', made from Ilex paraguariensis, widely consumed in South America, as mate con bombilla and mate cocido. Mate consumption has been associated with esophageal, oral, lung, and bladder cancers. This bladder cancer case-control study involved 114 Argentinean case-control pairs. Mate consumption was recorded for time of interview, and 20 and 40 years previously. Mate con bombilla consumed 20 years ago was associated with bladder cancer in ever-smokers (odds ratio=3.77, 95% confidence interval: 1.17-12.1), but not in never-smokers. Mate cocido was not associated with bladder cancer. These results are consistent with a previous study in Uruguay.

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    • "However, complex relationships in the mixture of substances in mate extract may also be involved in the overall disadvantageous effects of mate extract. Many reports showed that mate drinking may be correlated with the development of several cancer types [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] "
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    ABSTRACT: Despite its antioxidant capacity and well-known health benefits, yerba mate tea (Ilex paraguariensis) has been shown to possess some genotoxic and mutagenic activities and to increase incidence of some types of cancer. The aim of this study was to estimate the cyto- and genotoxicity of mate tea in human peripheral lymphocytes in vitro. We found that yerba mate extract induced a concentration-dependent, statistically significant increase in the level of apoptotic and necrotic cells and a decrease in the nuclear division index (NDI). Mate-exposed lymphocytes had a reduced transcriptional rDNA activity, which may be due to the stress conditions, and showed an elevated production of micronuclei. The FISH technique revealed the appearance of an acrocentric signal in mate-induced micronuclei, which suggests that under these conditions yerba mate extract may display aneugenic activity. Since caffeine is one of the most abundant compounds found in the dry mass of mate, we conducted additional experiments with caffeine alone. We showed that caffeine used at the same concentrations manifests a more potent cyto- and genotoxic effect that may account, at least in part, for the disadvantageous effects observed for yerba mate extract.
    Mutation Research/Genetic Toxicology and Environmental Mutagenesis 10/2009; 679(1-2):18-23. DOI:10.1016/j.mrgentox.2009.07.017 · 2.42 Impact Factor
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    • "Not only has Mate tea been shown to contain high concentrations of bioactive compounds, it has also been shown to be cytotoxic to human cancer hepatoma cells (HepG2), and can act as a catalytic inhibitor of topoisomerase II (Ramirez-Mares and others 2004). On the other hand, some epidemiological studies have reported an association between the consumption of Mate tea and an increased risk of various types of cancer, including oral, oropharyngeal , esophageal, laryngeal, and bladder (Goldenberg and others 2003; Sewram and others 2003; Bates and others 2007). "
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    ABSTRACT: Yerba Mate tea, an infusion made from the leaves of the tree Ilex paraguariensis, is a widely consumed nonalcoholic beverage in South America which is gaining rapid introduction into the world market, either as tea itself or as ingredient in formulated foods or dietary supplements. The indigenous people have used it for centuries as a social and medicinal beverage. Yerba Mate has been shown to be hypocholesterolemic, hepatoprotective, central nervous system stimulant, diuretic, and to benefit the cardiovascular system. It has also been suggested for obesity management. Yerba Mate protects DNA from oxidation and in vitro low-density lipoprotein lipoperoxidation and has a high antioxidant capacity. It has also been reported that Yerba Mate tea is associated to both the prevention and the cause of some types of cancers. Yerba Mate has gained public attention outside of South America, namely the United States and Europe, and research on this tea has been expanding. This review presents the usage, chemistry, biological activities, health effects, and some technological considerations for processing of Yerba Mate tea. Furthermore, it assesses in a concise and comprehensive way the potential of Ilex paraguariensis as a source of biological compounds for the nutraceutical industry.
    Journal of Food Science 12/2007; 72(9):R138-51. DOI:10.1111/j.1750-3841.2007.00535.x · 1.70 Impact Factor
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    • "One additional case-control from Argentina study was characterized by a strong direct association between coffee consumption and bladder cancer, but no effect of maté drinking [25]. Finally, in a recent case-control study conducted in Córdoba, Argentina, maté was associated with bladder cancer risk [26]. No data were previously reported on effect of temperature of maté on bladder cancer risk. "
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    ABSTRACT: Bladder cancer is the fourth most frequent malignancy among Uruguayan men. A previous study from Uruguay suggested a high risk of bladder cancer associated with maté drinking. We conducted an additional case-control study in order to further explore the role of non-alcoholic beverages in bladder carcinogenesis. In the time period 1996-2000, 255 incident cases with transitional cell carcinoma of the bladder and 501 patients treated in the same hospitals and in the same time period were frequency matched on age, sex, and residence. Both cases and controls were face-to-face interviewed on occupation, tobacco smoking, alcohol drinking and intake of maté, coffee, tea, and soft drinks. Statistical analysis was carried out by unconditional multiple logistic regression. Ever maté drinking was positively associated with bladder cancer (odds ratio [OR] 2.2, 95% confidence interval [CI] 1.2-3.9) and the risk increased for increasing duration and amount of maté drinking. Both coffee and tea were strongly associated with bladder cancer risk (OR for coffee drinking 1.6, 95% CI 1.2-2.3; OR for tea drinking 2.3, 95% CI 1.5-3.4). These results were confirmed in a separate analysis of never-smokers. Our results suggest that drinking of maté, coffee and tea may be risk factors for bladder carcinoma in Uruguay.
    BMC Cancer 03/2007; 7(1):57. DOI:10.1186/1471-2407-7-57 · 3.36 Impact Factor
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