Article

Serum albumin level and nosocomial pneumonia in stroke patients

Department of Neurology, Jagiellonian University, Krakow, Poland.
European Journal of Neurology (Impact Factor: 3.85). 04/2006; 13(3):299-301. DOI: 10.1111/j.1468-1331.2006.01210.x
Source: PubMed

ABSTRACT Hypoalbuminemia is associated with increased risk of infections. The aim of this study was to determine if serum albumin level is an independent predictor of nosocomial pneumonia in stroke patients. Data of 705 consecutive ischemic stroke patients admitted within 24 h after stroke onset were analyzed retrospectively. Serum albumin level was measured within 36 h after stroke onset. Nosocomial pneumonia was found in 10.5% of stroke patients. Patients with pneumonia had significantly lower serum albumin level than those without pneumonia (31.9 +/- 7.5 g/l vs. 35.5 +/- 6.9 g/l) and serum albumin level was associated with risk of pneumonia on multivariate analysis (OR: 0.95, 95% CI: 0.91-0.98). Our results show that serum albumin level is an independent predictor of nosocomial pneumonia in stroke patients.

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    • "Hypoalbuminemia was reported in up to 19% of stroke patients (Davalos et al., 1996; Gariballa et al., 1998; Davis et al., 2004). Stroke patients with hypoalbuminemia at admission had increased risk of infective complications (Gariballa et al., 1998; Dziedzic et al., 2006), death (Gariballa et al., 1998; Davis et al., 2004) and poor functional outcome (Davalos et al., 1996; Gariballa et al., 1998). "
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    ABSTRACT: Hypoalbuminemia in acute stroke patients is associated with increased mortality and morbidity. The aim of our study was to determine the frequency and correlates of hypoalbuminemia in unselected cohort of patients with acute cerebral infarction. Prospective study. University hospital. Seven hundred and five consecutive ischemic stroke patients. Albumin and other serum protein fractions were measured within 36 h after stroke using electrophoresis. Hypoalbuminemia defined as serum albumin level <35 g/l was found in 45.5% of patients. Serum albumin level correlates significantly with age (r=-0.13, P<0.01), Scandinavian Stroke Scale score (r=0.14, P<0.01), body temperature on admission (r=0.14, P<0.01), leukocyte count (r=-0.17, P<0.01), fasting glucose (r=-0.16, P<0.01), total cholesterol (r=0.14, P<0.01), alpha1-globulin (r=-0.48, P<0.01), alpha2-globulin (r=-0.49, P<0.01), beta-globulin (r=-0.26, P<0.01) and gamma-globulin (r=-0.35, P<0.01). Hypoalbuminemia is a frequent finding in acute stroke patients and it is associated with more severe stroke and pro-inflammatory pattern of serum protein electrophoresis.
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    • "It combines many types of substances and maintains colloid osmotic pressure (Kass and Lipton, 1989). Albumin not only has neuroprotective effects against stroke (Parkkinen et al., 2007; Koch et al., 2004), but is also a new biological marker of ischemia (Abboud et al., 2007; Dziedzic et al., 2006). Therefore, we hypothesized that albumin could help adult neocortical neurons to live in vitro. "
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