Article

Effects of oral glutamine supplementation on children with solid tumors receiving chemotherapy.

Department of Pediatric Metabolism and Nutrition, Gazi University Faculty of Medicine, Ankara, Turkey.
Pediatric Hematology and Oncology (impact factor: 0.89). 07/2006; 23(4):277-85. DOI:10.1080/08880010600628926 pp.277-85
Source: PubMed

ABSTRACT In recent years, there have been reports that glutamine support improves immune functions in adult patients with malignancy, but there is a lack of data in children. Oral glutamine support of 4 g/m2/day was given to 21 children with various solid tumors, aged 1-17 years (9.86 +/- 5.38) for all 5 days of a chemotherapy course. The same parameters in another course of the same protocol without glutamine supplementation were considered as controls. There were significant improvements of some nutritional and immunological parameters in the glutamine-supplemented course. Also glutamine seemed to reduce antibiotic necessity. Oral glutamine supplementation could be considered in children with solid tumors receiving chemotherapy.

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Keywords

21 children
 
adult patients
 
antibiotic necessity
 
chemotherapy
 
chemotherapy course
 
children
 
glutamine
 
glutamine supplementation
 
glutamine support
 
glutamine-supplemented course
 
immune functions
 
malignancy
 
Oral glutamine supplementation
 
Oral glutamine support
 
recent years
 
solid tumors
 
various solid tumors