Osteosarcoma Anatomic and Histologic Variants

Department of Pathology, University of Alabama at Birmingham and the Birmingham Veterans Affairs Medical Center 35233, USA.
American Journal of Clinical Pathology (Impact Factor: 2.51). 05/2006; 125(4):555-81. DOI: 10.1309/UC6K-QHLD-9LV2-KENN
Source: PubMed


Osteosarcoma is the most common primary tumor of bone, yet its absolute incidence among malignant tumors is low. Within its strict histologic definition, osteosarcoma comprises a family of lesions with considerable diversity in histologic features and grade. Its prognosis is dependent not only on these parameters, but also on its anatomic site. It may occur inside the bones (in the intramedullary or intracortical compartment), on the surfaces of bones, and in extraosseous sites. Information of diagnostic or prognostic significance has not been elucidated from studies of its cytogenetics. This review summarizes the anatomic and histologic variations of osteosarcoma and offers a schema for its subclassification.

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Available from: Gene P Siegal,
    • "Given its diverse histological classification, it is therefore hypothesized that osteosarcoma originates from a multipotent cell (Klein and Siegal 2006; Mohseny et al 2009). Although surgery and neo-adjuvant chemotherapy have improved outcome remarkably the main clinical problem of this tumor is its unpredictable recurrence or metastasis, which is likely the result of a few resistant tumor cells. "
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    • "Osteosarcoma (OS) is the most common primary malignant tumor of the bone. This neoplasm is defined histologically by osteoid deposition by the malignant mesenchymal cells [1]. In OS, current evidence supports an osteoblastic population as the cell of origin [2], although the distinct histological subtypes (e.g. "
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    • "ESOS, which is a malignant mesenchymal neoplasm, produces osteoid, bone or chondroid material, and it is commonly located in soft tissues without attachment to the skeleton. It is rare, and is reported in fewer than 2% of all soft tissue sarcomas [2]. The heart is an extraordinary site for osteosarcoma. "
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