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Histone Lysine Demethylases and Their Impact on Epigenetics

Howard Hughes Medical Institute, Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA.
Cell (Impact Factor: 33.12). 05/2006; 125(2):213-7. DOI: 10.1016/j.cell.2006.04.003
Source: PubMed

ABSTRACT Methylation marks on the lysine residues of histone proteins are thought to contribute to epigenetic phenomena in part because of their apparent irreversibility. Will this view change with the recent discovery of histone lysine demethylases that reversibly remove methyl marks?

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    • "Amongst this group, lysine histone demethylases are protein lysine demethylases, which act on histone and non-histone proteins [43] [44]. Major function of this group of enzymes is to mediate epigenetic regulation of gene transcription at the chromatin level [44]. Histone demethylases have important role in various cellular processes like cell cycle progression, nuclear hormone mediated and NF-kB signalling, p53 regulation, transcripttional regulation of Hox genes, fetoplacental development , regulation of DNA replication and repair processes [45] [46]. "
    Advances in Bioscience and Biotechnology 10/2012; 03(06). DOI:10.4236/abb.2012.326093
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    • "How a single transcription factor achieves gene transcription selectively is unsolved question for long time. Epigenetic markers and molecules emerged to be key players in gene transcription (Campos and Reinberg, 2009; Chi et al., 2010; Eissenberg and Shilatifard, 2009; Smith et al., 2011; Suganuma and Workman, 2010; Trojer and Reinberg, 2006). MLL1 and MLL2 were shown to be recruited by p52 to the promoter of MMP9 (matrix metallopeptidase 9) in a T cell lymphoma cell line (Robert et al., 2009). "
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    • "It seems that supplementation of nutraceuticals and wild foods as well as wild lifestyle may be protective, whereas western diet and lifestyle may enhance the expression of genes related to chronic diseases. Our *Address correspondence to this author at the Department of Biotechnology, College of Engineering & Technology IFTM Campus, Delhi Road, Moradabad 244001, U.P., India; Tel: +91-591-2360817; Fax: +91-591-2360818; E-mail: sanjaymishra66@gmail.com genes or pathways are most likely regulated by microRNA [1] [2] [3] [4]. The prevalence and mortality due to multifactorial polygenic diseases; hypertension, coronary artery disease (CAD), diabetes and cancer vary depending upon genetic susceptibility and environmental precursors because they have identifiable Mendelian subsets. "
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