Article

Neurogenesin-1 differentially inhibits the osteoblastic differentiation by bone morphogenetic proteins in C2C12 cells.

Department of Biochemistry, Hamamatsu University School of Medicine, 1-20-1 Handa-yama, Hamamatsu 431-3192, Japan.
Biochemical and Biophysical Research Communications (impact factor: 2.48). 07/2006; 344(3):786-91. DOI:10.1016/j.bbrc.2006.03.195 pp.786-91
Source: PubMed

ABSTRACT Bone morphogenetic protein (BMP) antagonists regulate the pleiotropic actions of BMPs by binding to BMPs. We previously isolated the Neurogenesin-1 (Ng1) gene and found that Ng1 protein induces neuronal differentiation in the brain. In this study, we found that Ng1 was expressed in the primordial cells of the skeleton and investigated whether Ng1 protein inhibited the BMP action to induce osteoblastic differentiation in C2C12 myoblasts. Interestingly, Ng1 protein inhibited the BMP7-induced alkaline phosphatase activity while it did not inhibit the BMP2-induced activity. All data suggest that Ng1 protein plays an important role in the embryonic bone formation by differentially regulating BMPs.

0 0
 · 
0 Bookmarks
 · 
26 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

BMP action
 
BMP2-induced activity
 
BMP7-induced alkaline phosphatase activity
 
Bone morphogenetic protein
 
C2C12 myoblasts
 
differentially regulating BMPs
 
embryonic bone formation
 
induce osteoblastic differentiation
 
Interestingly
 
Ng1 protein induces neuronal differentiation
 
pleiotropic actions
 
primordial cells
 

Abhishek Chandra