Pulmonary vein stenosis following repair of total anomalous pulmonary venous connection.
ABSTRACT Pulmonary vein stenosis may occur following the repair of total anomalous pulmonary venous connection and carries a poor prognosis. Conventional surgical therapies have been complicated by a high rate of re-stenosis. Sutureless pericardial marsupialization has been introduced as a technique to reduce the rate of re-stenosis. This report describes a retrospective review of a group of patients undergoing repair of acquired pulmonary vein stenosis. Presence of single-ventricle anatomy was found to be the primary preoperative risk factor for a poor outcome. The use of sutureless pericardial marsupialization was found to be associated with a significant improvement in disease-free survival.
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Conference Paper: On-orbit model refinement for controller redesign[Show abstract] [Hide abstract]
ABSTRACT: High performance control design for a flexible space structure is challenging since high fidelity plant models are difficult to obtain a priori. Uncertainty in the control design models typically require a very robust, low performance control design which must be tuned on-orbit to achieve the required performance. A new procedure for refining a multivariable open loop plant model based on closed-loop response data is presented. Using a minimal representation of the state space dynamics, a least squares prediction error method is employed to estimate the plant parameters. This control-relevant system identification procedure stresses the joint nature of the system identification and control design problem by seeking to obtain a model that minimizes the difference between the predicted and actual closed-loop performance. This paper presents an algorithm for iterative closed-loop system identification and controller redesign along with illustrative examplesAerospace Conference, 1998 IEEE; 04/1998
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ABSTRACT: The mitochondrial degradosome (mtEXO) of S. cerevisiae is the main exoribonuclease of yeast mitochondria. It is involved in many pathways of mitochondrial RNA metabolism, including RNA degradation, surveillance, and processing, and its activity is essential for mitochondrial gene function. The mitochondrial degradosome is a very simple example of a 3' to 5'-exoribonucleolytic complex. It is composed of only two subunits: Dss1p, which is an RNR (RNase II-like) family exoribonuclease, and Suv3p, which is a DExH/D-box RNA helicase. The two subunits form a tight complex and their activities are highly interdependent, with the RNase activity greatly enhanced in the presence of the helicase subunit, and the helicase activity entirely dependent on the presence of the ribonuclease subunit. In this chapter, we present methods for studying the function of the yeast mitochondrial degradosome in vivo, through the analysis of degradosome-deficient mutant yeast strains, and in vitro, through heterologous expression in E. coli and purification of the degradosome subunits and reconstitution of a functional complex. We provide the protocols for studying ribonuclease, ATPase, and helicase activities and for measuring the RNA binding capacity of the complex and its subunits.Methods in enzymology 02/2008; 447:463-88. DOI:10.1016/S0076-6879(08)02222-2 · 2.19 Impact Factor
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ABSTRACT: Active perioperative intervention and improvement on surgical technique has decreased the mortality rate of total anomalous pulmonary venous connection (TAPVC); however, when complicated with pulmonary venous obstruction, operative mortality is still high. The purpose of this study was to investigate the clinical course of TAPVC.Korean Journal of Pediatrics 01/2009; 52(2). DOI:10.3345/kjp.2009.52.2.194