Update on recommendations for assessing response from the Third International Workshop on Waldenstrom's Macroglobulinemia.
ABSTRACT This report by an international consensus panel updates current recommendations for defining clinical response in Waldenstrom's macroglobulinemia (WM). The previously published response criteria incorporated parameters for monoclonal protein reduction and/or improvement of marrow and nodal involvement, and included definitions of complete and partial remissions. The criteria have been updated to include minor response and stable disease categories. In addition, the criteria now recognize that delayed responses after treatment with nucleoside analogues and biologic agents and the time point for assessing response in patients with WM should be considered so as to not miss or miscategorize a response. The new criteria should therefore help in better delineating responses to therapy in patients with WM, particularly with the wide use of nucleoside analogues and biologically based agents for this disease.
- SourceAvailable from: Sergio Nery Simoes[Show abstract] [Hide abstract]
ABSTRACT: Various statistical and machine learning based algorithms have been proposed in literature for selecting an informative subset of genes from microarray data sets. The recent trend is to use functional knowledge to aid the gene selection process. In this paper we propose a clustering algorithm which generates multiple views (clusters) from the microarray expression profiles, each representing a particular facet of the data. Such multiple clusters are found to represent strongly connected regions of the known protein–protein interaction (PPI) networks, perhaps corresponding to those responsible for certain biological processes. Thus we integrate microarray data clustering with PPI knowledge to obtain enriched gene sets. Results on benchmark microarray data sets demonstrate the competitiveness of our method compared to gene selection techniques.IEEE International Conference on BioInformatics and BioEngineering, Boca Raton; 11/2014
- Turkish Journal of Haematology 12/2013; 30(4):422-3. · 0.49 Impact Factor
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ABSTRACT: The combination of bortezomib and rituximab was evaluated in patients with mantle cell lymphoma (MCL), follicular lymphoma (FL) and Waldenström macroglobulinaemia (WM), in a Phase I and later, a randomized Phase II study. In the randomized study, 42 patients with recurrent/refractory disease received either: bortezomib 1·3 mg/m(2) on days 1, 4, 8 and 11 of a 3-week cycle with rituximab 375 mg/m(2) on day 1 (21 patients) or: bortezomib 1·6 mg/m(2) and rituximab on days 1, 8, 15 and 22 of a 5-week cycle (with rituximab being given only in cycles 1 and 4).Twenty-eight patients were withdrawn (toxicity 16, progression 7, and 'patient choice' 5). The main toxicities were neurological, gastro-intestinal and haematological. The overall response rate was 28/42(67%) and by histology: MCL 11/19, FL 8/15, and WM 9/10. Ten of 28 responding patients remained progression-free at 1-3·5 years. Toxicity and efficacy were equivalent between the two groups. The combination has significant toxicity but is effective, particularly in patients with WM.British Journal of Haematology 11/2010; 151(4):346-53. · 4.94 Impact Factor