Article

Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region

Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States
Science (Impact Factor: 31.48). 05/2006; 312(5773):577-9. DOI: 10.1126/science.1124153
Source: PubMed

ABSTRACT We surveyed an Anopheles gambiae population in a West African malaria transmission zone for naturally occurring genetic loci that control mosquito infection with the human malaria parasite, Plasmodium falciparum. The strongest Plasmodium resistance loci cluster in a small region of chromosome 2L and each locus explains at least 89% of parasite-free mosquitoes in independent pedigrees. Together, the clustered loci form a genomic Plasmodium-resistance island that explains most of the genetic variation for malaria parasite infection of mosquitoes in nature. Among the candidate genes in this chromosome region, RNA interference knockdown assays confirm a role in Plasmodium resistance for Anopheles Plasmodium-responsive leucine-rich repeat 1 (APL1), encoding a leucine-rich repeat protein that is similar to molecules involved in natural pathogen resistance mechanisms in plants and mammals.

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    • "Several studies have been performed by distinct research groups allowing the characteristics of P. falciparum inside some important vectors from Africa and Asia, including the molecular aspects of the interaction and the immune response to the parasite infection to be understood (Rodrigues et al. 2012, Ramirez et al. 2014). Additionally, studies have shown that mosquito species exhibit a wide range of susceptibility to infection with a given P. falciparum line (Collins et al. 1986, Lambrechts et al. 2005) and different Plasmodium isolates also vary in their ability to infect a given mosquito strain (Niare et al. 2002, Lambrechts et al. 2005, Riehle et al. 2006). A degree of adaptation was suggested between geographically isolated populations of An. gambiae and P. falciparum when an An. "
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