Efforts toward oral bioavailability in factor VIIa inhibitors.
Celera, 180 Kimball Way, South San Francisco, CA 94979, USA.Bioorganic & Medicinal Chemistry Letters (Impact Factor: 2.34). 08/2006; 16(14):3829-32. DOI:10.1016/j.bmcl.2006.04.018
ABSTRACT Efforts toward developing orally bioavailable factor VIIa inhibitors starting from parenteral lead compound 1 are described. SAR resulted in improved physicochemical properties, leading to enhanced oral absorption in rat.
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