[Show abstract][Hide abstract] ABSTRACT: The epithelial to mesenchymal transition (EMT) which is a pathologic phenomenon in cancer has a twin in embryonic period of life. In the first one its promotion will cause metastasis to become a life threatening stage of cancer while in the second one, it will lead to organogenesis which is necessary for all living creatures. There is one more from this phenomenon, which occurs during wound healing process and if dys-regulated can lead to fibrosis. In both there are stimulants in common and different. Stages start from cell-cell junction dissociation followed by morphological changes and behavioral and essence alterations. To control the EMT as a bizarre disturbance in cancer and metastasis, initially it is better to understand the wonder of natural gestational orchestration in early life. In this review first the structure of the two head of the spectrum is described followed by the cellular and micro-environmental alterations during this phenomenon. Understanding cellular behavior in this process and what makes them invasive resistant stemness cells will be of great importance in highlighting roads to cancer treatment.
Cancer Science 11/2012; 104(1). DOI:10.1111/cas.12074 · 3.52 Impact Factor
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