Corrosive induced carcinoma of esophagus: Report of three patients and review of literature
ABSTRACT Patients with corrosive induced esophageal strictures have more than a 1000-fold risk of developing carcinoma of the esophagus. We report three cases of corrosion carcinoma seen by us (a team of gastroenterologists, radiologists and a surgeon) in the last 15 years. Two cases were among 156 patients with corrosive induced strictures on our follow-up, and constituted the only corrosion carcinoma out of 650 esophageal carcinomas operated on by us. Nearly all reported patients with corrosion carcinoma in the published literature had consumed an alkali, but two of our three patients had consumed an acid.
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ABSTRACT: Esophageal cancer is a significant cause of cancer morbid-ity and mortality worldwide, with dramatic geographical variation in incidence. In the US there has been a dramatic shift in histology within the past decades, with adenocarcinoma now being more prevalent than squamous histologies. The reasons for this are not clearly understood at this time. Squamous cell carcinoma is still more prevalent worldwide, and typically seen in the upper 2/3 of the esophagus. It is associated with repeated mucosal insults, including tobacco. Adenocarcinoma is more common in the distal esophagus, and more closely associated with obesity and GERD. Current research is looking into tumor suppressor genes and molecular pathways to further elucidate the pathogenesis of this disease.
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ABSTRACT: A 29-year-old woman who swallowed oil cleaner (strong hydroxide: NaOH) by mistake received conservative therapy because of having neither mediastinitis nor peritonitis. She complained of dysphagia 1 month after ingestion. Upper gastrointestinal series showed severe stricture in the middle and lower thoracic esophagus and in the antrum of the stomach. Gastrostomy and jejunostomy were performed on the 87th day after ingestion. Transthoracic subtotal esophagectomy and total gastrectomy followed by esophageal reconstruction using the colon with microvascular anastomosis through a retrosternal route was performed on the 148th day after the ingestion. On open thoracotomy, although dense mediastinal adhesions were found around the esophagus, esophagectomy could be achieved successfully. She was discharged 22 days after the second surgery without postoperative complication.Esophagus 09/2012; 9(3). DOI:10.1007/s10388-012-0313-0 · 0.74 Impact Factor