Article

3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: Conformational analysis and biological activity

Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK.
Bioorganic & Medicinal Chemistry Letters (Impact Factor: 2.33). 08/2006; 16(14):3839-42. DOI: 10.1016/j.bmcl.2006.04.019
Source: PubMed

ABSTRACT Previously, chemistry effort on the gem-cyclohexane series of gamma-secretase inhibitors has focused on the 4-position of the cyclohexane ring. Recently chemistry has been directed towards the 3-position and substitution here has also provided compounds with high gamma-secretase activity.

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