Article

Successful treatment of Trichosporon mucoides infection with lipid complex amphotericin B and 5-fluorocytosine.

Mycoses (impact factor: 2.25). 06/2006; 49(3):251-3. DOI:10.1111/j.1439-0507.2006.01223.x
Source: PubMed

ABSTRACT Infections in immunocompromised children can stem from bacteria, fungi, viruses, or protozoa, but most importantly, from the host's endogenous bacterial flora. Disseminated infection caused by Trichosporon species is one of the emerging mycoses in neutropenic patients, particularly when they are treated for haematological malignancy with cytotoxic and immunosuppressive chemotherapy. We report a 15-year-old boy with acute lymphoblastic leukaemia, whose Trichosporon mucoides infection was successfully treated with lipid complex amphotericin B plus 5-fluorocytosine.

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  • Article: Trichosporon mycotoxinivorans, a novel respiratory pathogen in patients with cystic fibrosis.
    Patrick W Hickey, Deanna A Sutton, Annette W Fothergill, Michael G Rinaldi, Brian L Wickes, Howard J Schmidt, Thomas J Walsh
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    ABSTRACT: This report describes the molecular epidemiology, in vitro susceptibility, colonial and microscopic morphologies, and biochemical features of Trichosporon mycotoxinivorans, a newly recognized pathogen that appears to have a propensity for patients with cystic fibrosis. The index patient died with histologically documented Trichosporon pneumonia complicating cystic fibrosis. This is also the first report of disease caused by a Trichosporon species in a nontransplant patient with cystic fibrosis. As T. mycotoxinivorans has not previously been recognized as a respiratory pathogen, the significance of its recovery from sputum samples was not initially appreciated. Genetic analysis of archived clinical samples found three additional cases of T. mycotoxinivorans infection which had previously been identified as other members of the genus. An additional isolate of T. mycotoxinivorans was identified from a clinical sample on initial testing. Three of these four cases were also patients with cystic fibrosis. All isolates had MICs at 48 h of amphotericin B of > or = 1 microg/ml and of echinocandins of > or = 16 microg/ml, but they displayed various susceptibilities to the triazoles. In summary, Trichosporon mycotoxinivorans is a newly recognized human pathogen that is associated with cystic fibrosis.
    Journal of clinical microbiology 08/2009; 47(10):3091-7. · 4.16 Impact Factor
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Keywords

15-year-old boy
 
5-fluorocytosine
 
acute lymphoblastic leukaemia
 
Disseminated infection
 
emerging mycoses
 
haematological malignancy
 
immunosuppressive chemotherapy
 
Infections
 
lipid complex amphotericin B
 
Trichosporon mucoides infection
 
Trichosporon species
 

Tanil Kendirli