Disseminated cryptococcosis in a patient with nephrotic syndrome.
ABSTRACT Disseminated cryptococcosis mainly occurs in patients with impaired cell mediated immunity. We present a case of disseminated cryptococcosis in a non-HIV patient with nephrotic syndrome who never received immunosuppression. Cultures of bone marrow aspirate, cerebrospinal fluid analysis and histology of skin lesions were all consistent with Cryptococcus neoformans infection. Treatment with amphotericin B followed by fluconazole was successful and in the course of two months when, the skin nodules disappeared.
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ABSTRACT: Objective To study disseminated cryptococcal infection in a tertiary care hospital in Southern India.Asian Pacific Journal of Tropical Medicine 10/2010; 3(10):818-820. · 0.93 Impact Factor
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ABSTRACT: Cryptococcus neoformans has a worldwide distribution. Meningoencephalitis is the most common manifestation of cryptococcosis. The outcome of a patient with cryptococcal infection depends on the immune status of the host. Patients with nephrotic syndrome are particularly susceptible to cryptococcal infection not only due to innate changes in their immune system but also because of the immunosuppressive agents used in the treatment. We report an 8-year-old boy with nephrotic syndrome, who developed cryptococcal meningitis and died of fulminant intracranial hypertension.Indian Journal of Critical Care Medicine 07/2011; 15(3):176-8.