Article

Partial-discard strategy for obtaining high purity products using simulated moving bed chromatography.

Department of Chemical Engineering, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-749, South Korea.
Journal of Chromatography (impact factor: 4.53). 08/2006; 1122(1-2):161-73. DOI:10.1016/j.chroma.2006.04.040
Source: PubMed

ABSTRACT A new "partial-discard" operation strategy was developed to improve the performance, especially purity, achievable in simulated moving bed (SMB) chromatography. This strategy was applied to the four-zone SMB process with two columns per zone for binary separation within the linear range. The "partial-discard" strategy significantly enhanced the purity or enrichment when the discard time and discard length were controlled. In addition, the "partial-feed with partial-discard" strategy improved remarkably the extract and raffinate purities at an intermediate feed time compared with the "partial-feed" operation. Adjustments of the discard length and discard time played key roles in achieving the desired product purity in SMB chromatographic performance.

0 0
 · 
0 Bookmarks
 · 
38 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

achievable
 
binary separation
 
columns
 
desired product purity
 
discard length
 
discard time
 
enrichment
 
four-zone SMB process
 
intermediate feed time
 
key roles
 
new
 
operation strategy
 
partial-discard
 
partial-feed
 
raffinate purities
 

Youn-Sang Bae