Is there a common neuronal basis for autism and catatonia?

Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
International Review of Neurobiology (Impact Factor: 2.46). 02/2006; 72:151-64. DOI: 10.1016/S0074-7742(05)72009-2
Source: PubMed

ABSTRACT Neuronal bases for autism and catatonia are unknown although integrative theories may soon become feasible as research in autism and catatonia advances. Catatonia and autism may both qualify as neurobiological syndromes in their own right. There is emerging evidence that catatonia may be a common syndrome in autism. Although the relation between autism and catatonia is unclear, coexpression of autism and catatonia may be due to abnormalities in common neuronal circuitries. This possibility constitutes another level of complexity to neurobiological inquiry, but also provides an opportunity to advance our understanding of both disorders. There is a great potential benefit in studying the relation between catatonia and autism in order to focus future research on subtype-specific causes and treatments. Future research avenues are outlined.

  • Source
    The Journal of neuropsychiatry and clinical neurosciences 07/2013; 25(3):E13. DOI:10.1176/appi.neuropsych.11120367 · 2.77 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A systematic review was conducted to examine the efficacy of a range of treatments for autistic catatonia. The review identified 22 relevant papers, reporting a total of 28 cases including both adult and paediatric patients. Treatment methods included electroconvulsive therapy (ECT), medication, behavioural and sensory interventions. Quality assessment found the standard of the existing literature to be generally poor, with particular limitations in treatment description and outcome measurement. There is some limited evidence to support the use of ECT, high dose lorazepam and behavioural interventions for people with autistic catatonia. However, there is a need for controlled, high-quality trials. Reporting of side effects and adverse events should also be improved, in order to better evaluate the safety of these treatments.
    Journal of Autism and Developmental Disorders 03/2014; 44(9). DOI:10.1007/s10803-014-2085-y · 3.06 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Nach Angaben der WHO besteht bei 1–3% der Bevölkerung eine geistige Behinderung (GB). Bei etwa jedem 4.Menschen mit GB besteht zusätzlich eine Autismusspektrumstörung (24,6%, Mittelwert aus 19 Studien, n=9675), wobei die Prävalenz mit dem Grad der GB ansteigt (IQ 50–70: 9,9%, IQ<50: 31,7%). Besonders für die behandelnden Ärzte von psychisch kranken oder verhaltensauffälligen Menschen mit GB ist es daher wichtig, die Störung zu erkennen, differenzialdiagnostisch abzuklären und therapeutische Schritte einzuleiten. Die Diagnose basiert – unabhängig vom IQ – auf einer vor dem 3.Lebensjahr begonnenen Beeinträchtigung in den Kernbereichen soziale Interaktion, Kommunikation und eingeschränkten, repetitiven Interessen (frühkindlicher oder Kanner-Autismus). Auch bei Menschen mit einer GB kann Autismus als zusätzliche, eigenständige Störung diagnostiziert werden, wobei die kommunikativen und sozialen Fähigkeiten in Relation zum Intelligenz- und Entwicklungsniveau zu setzen sind. Aufgrund der reduzierten Ausdrucks- und Introspektionsfähigkeit, der erhöhten Prävalenz körperlicher und psychischer Erkrankungen, der erschwerten Anamnesebedingungen und der u.U. atypischen Symptompräsentation ist die Diagnosestellung bei erwachsenen Menschen mit GB eine besondere Herausforderung. Der vorliegende Artikel beschreibt die Symptomatik, das diagnostische Vorgehen, häufige Komorbiditäten und Differenzialdiagnosen sowie therapeutische Möglichkeiten und Grenzen bei erwachsenen Menschen mit Intelligenzminderung und Autismusverdacht. According to the World Health Organization (WHO) the estimated prevalence of intellectual disabilities (ID) is about 1–3% and 1 out of 4 individuals with ID suffer from an additional autistic spectrum disorder (ASD) (arithmetic mean 24.6%, 19 studies, n=9,675) whereby the prevalence increases with the severity of ID (IQ 50–70: 9.9%, IQ<50: 31.7%). Therefore, it is of particular importance for physicians treating individuals with ID who have psychiatric disorders or behavioral problems to take ASD into account as a differential diagnosis so that appropriate treatment can be initiated. Irrespective of the IQ the diagnosis is based on an impairment of social interaction and communication and restricted repetitive interests presenting before the age of 3 (infantile or Kanner autism). ASD can be diagnosed as a separate disorder in adults with ID, however, the social and communicative abilities in respect of the cognitive and developmental level have to be considered. Due to reduced verbal capacity, high prevalence of physical and mental disorders, difficulties in taking the past medical history and presentation of atypical symptoms, the diagnostic assessment for autism in adults with ID is challenging. This article describes the typical symptoms, diagnostic approach, frequent comorbidities, differential diagnoses treatment options and their limitations for adults with ID suspected of having ASD. SchlüsselworterAutismus-Diagnose-Geistige Behinderung-Prognose-Therapie KeywordsAutism-Diagnosis-Mental retardation-Prognosis-Therapy
    Der Nervenarzt 11/2010; 81(11):1333-1345. DOI:10.1007/s00115-010-3098-1 · 0.86 Impact Factor


Available from
Jun 4, 2014